During chymotrypsin-mediated catalysis, which of the following statements is true? Select any/all answers that apply. OA. A basic (positively-charged) side chain of the substrate polypeptide sits within the oxyanion hole of the enzyme. O B. A basic (positively-charged) side chain of the substrate polypeptide sits within the specificity pocket of the enzyme. O C. Ser195 hydrogen-bonds with the backbone carbonyl group of the substrate polypeptide within the oxyanion hole of the enz O D. All three residues that comprise the catalytic triad of the enzyme interact directly with the substrate polypeptide chain. OE. Both covalent catalysis and acid-base catalysis occur.

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