drug y is a substrate of p-gp. If drug Y is administered orally with a P-gp inhibitor, its systemic exposure will be affected or not affected? (How will it be affected or not. Increase or decrease.).
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drug y is a substrate of p-gp. If drug Y is administered orally with a P-gp inhibitor, its systemic exposure will be affected or not affected?
(How will it be affected or not. Increase or decrease.). .
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- Need help, please. Based on the inserted curve, if this enzyme was Chymotrypsin, please explain how this behavior could make sense.Assighment. Create a diagram which illustrates the typical signalling mechanism of action of each of the four common classes of receptor (e.g. kinase-linked receptors etc.) and possible routes of communication (autocrine etc.). Your diagram should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. For each of the examples describe the mechanism of action in the form below. DO NOT use any of the ligand-receptor combinations provide to you in the Learning Materials to date - research and create a diagram for a novel pathway instead!Please ASAP. Thank you.
- Hi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.Please ASAP. Thankyou.Please ASAP. Thank you. Cyclic nucleotide gated channels (CNG ): Is this channel voltage sensitive? How is this channel gated?
- cancer. Describe how experiments can be performed and used to determine the accuracy, sensitivity and specificity of the device. Using your own hypothetical values, calculate the accuracy, sensitivity and specificity of the device. Is the device suitable for screening for breast cancer, based on your calculated valuesPlease ASAP. Thank you A nociceptor-specific knock-out mutation of Nav1.3 in mice resulted in typical neuropathic pain behavior. What genetic technique was used to create this site-specific mutation?Please ASAP. Thank you. Why would a medical doctor administer naloxone in addition to an opiate such as Fentanyl?