**Diagram Explanation:**The diagram illustrates a chemical structure involved in enzymatic activity. It depicts a molecule with several key functional groups:- A carbon chain connected to an "R" group, which represents a variable side chain.- A negatively charged oxygen atom bonded to a carbon.- A sulfur-containing group attached to Coenzyme A (CoA), indicating the presence of a thioester bond.- A ring structure resembling a pyrrole, marked with NH groups, and another aromatic ring suggesting an indole ring.- Additional CH2 groups connecting sections of the molecule.**Text Explanation:**3. Compare and contrast how thiolase and chymotrypsin create and stabilize their intermediates.**Discussion Points:**- **Thiolase:** - Involves catalytic mechanisms typically forming thioester intermediates. - Stabilizes intermediates through interactions with CoA and side chain groups. - **Chymotrypsin:** - A serine protease that stabilizes its tetrahedral intermediates through an oxyanion hole. - Utilizes a catalytic triad for processing peptide bonds.The comparison explores the mechanistic differences between these enzymes in intermediate formation and stabilization.

Enzymes are highly specialized proteins that have extraordinary catalytic power, greater than that…

Answered: 3. Compare and contrast how thiolase…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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9. In E. coli the synthesis of phosphatidylethanolamine directly involves: acyl carrier protein. biotin. CDP-choline. phosphatidylglycerol. serine.
2. Of the molecules shown below, which one would you expect to inhibit chymotrypsin most effectively? Why? B B VE TË NË TË N
3. From a cell's point-of-view, which one or more of the following is/are the most effective (and least detrimental) way to shift only the reaction A B toward the right. A) Increase [A] B) Decrease [A] C) Increase [B] D) Decrease [B] E) Increase the temperature
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2C. A “pulse-chase" experiment using "C-labeled glucose can be carried out on a yeast extract that is maintained under strictly anaerobic conditions. The experiment consists of incubating a small amount of "C-labeled substrate (the pulse) with the yeast extract just long enough for each intermediate in the fermentation pathway to become labeled. The label is then “chased" through the pathway by the addition of excess unlabeled glucose. The chase effectively prevents any further entry of labeled glucose into the pathway. 2 ADP 2 ATP Glucose ---> CH3 2 NAD* 2 NADH 2 Pyruvate H H H-C-OH C=0 CH3 CH3 2 co, 2 Ethanol 2 Acetylaldehyde (1) If [1-"C]glucose (glucose labeled at C-1 with "C) is used as a substrate, will there be any "C in the product (ii) Lactic acid is the final fermentation product in vertebrates, while ethanol is the final fermentation product in yeast. Lactic acid can be converted back into glucose while ethanol can not be. In the space below, use a thermodynamic rationale to…
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3. Compare and contrast how thiolase and chymotrypsin creates and stabilizes its intermediates.