1/V sec/mM -6-4-2 1.0 0.8 0.6 0.4 0.2 2 4 A B 6 8 10 1/[S] MM-1 inhibited enzyme uninhibited enzyme ✓ mixed There are two lines marked A and B, one of which represents kinetic data from an uninhibited enzyme and the other from the same enzyme in the presence of inhibitor 1. Line A represents inhibited enzyme Line B represents uninhibited enzyme What type of inhibitor is 1? mixed What is the Km of the uninhibited enzyme? (Please provide answer to two significant figures.) Number 0.17 0.170 Units mM mM What is the Vmax of the uninhibited enzyme? (Please provide answer to two significant figures) 5.00 Units mM/sec mm/sec Number 5

1/V sec/mM -6-4-2 1.0 0.8 0.6 0.4 0.2 2 4 A B 6 8 10 1/[S] MM-1 inhibited enzyme uninhibited enzyme ✓ mixed There are two lines marked A and B, one of which represents kinetic data from an uninhibited enzyme and the other from the same enzyme in the presence of inhibitor 1. Line A represents inhibited enzyme Line B represents uninhibited enzyme What type of inhibitor is 1? mixed What is the Km of the uninhibited enzyme? (Please provide answer to two significant figures.) Number 0.17 0.170 Units mM mM What is the Vmax of the uninhibited enzyme? (Please provide answer to two significant figures) 5.00 Units mM/sec mm/sec Number 5

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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ntegrated LabCase Study DiabetesJohn is a 50 yr old man admitted to your medical unit with an ulceration on his right ankle. His blood glucose level is 473. He tells you he takes NPH (Humilin N) insulin 40 units every morning and Regular insulin with each meal and at bedtime.John’s first dose of insulin each day is given at 6 am. Chart the action of this insulin throughout the day, showing what time the insulin was given and where it peaks.Hint: This is referring to the NPH. Look up peak times for this.John said his doctor told him to keep his glucose between 100 and 150. What is the normal range for blood glucose.
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Question 1a. What is the direction of shift of a dose-response curve when a reversible competitive antagonist is present at a fixed concentration? Up Down Left Right Down and right Question 1b. When the antagonist is competitive and reversible how does the Emax change? It is unchanged It is increased It is decreased Question 1c. When the antagonist is competitive and reversible how does the ED50 change? It is unchanged It is increased It is decreased Question 2a. What is the direction of shift of a dose -response curve when an irreversible competitive antagonist is present at a fixed concentration. Up Down Left Right Down and right Question 2b. When the antagonist is competitive and irreversible how does the Emax change? It is unchanged It is increased It is decreased Question 2c. When the antagonist is competitive and irreversible how does the ED50 change? It is unchanged It is increased It is decreased Question 3a. What is the direction of shift of a dose…
ve this response. Question 2 Nurse O'Riordan has to give ceftriaxone to a 5-year old weighing 18 kg. The recommended dose is 100 mg/kg. How much does she have to give?