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The enzyme dihydroneopterin aldolase (DHNA) is found in the metabolic pathway leading to folic acid. The enzyme catalyzes the reaction below, the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropeterin (HP) and glycoaldehyde (GA), the third step in the biosynthetic path to folic acid. The enzyme also catalyzes the epimerization of 7,8-dihydroneopterin to 7,8-dihydro-L-monopterin (DHMP). Provide a chemical mechanism that can account for the formation of both of these products. Be sure to show the involvement of enzyme residues that might facilitate each step in the mechanism. OH HN မင်း ОН H₂N "N DHNP OH HN H₂N N DHMP HN H₂N HP N OH OH OH OH GA OH

The enzyme dihydroneopterin aldolase (DHNA) is found in the metabolic pathway leading to folic acid. The enzyme catalyzes the reaction below, the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropeterin (HP) and glycoaldehyde (GA), the third step in the biosynthetic path to folic acid. The enzyme also catalyzes the epimerization of 7,8-dihydroneopterin to 7,8-dihydro-L-monopterin (DHMP). Provide a chemical mechanism that can account for the formation of both of these products. Be sure to show the involvement of enzyme residues that might facilitate each step in the mechanism. OH HN မင်း ОН H₂N "N DHNP OH HN H₂N N DHMP HN H₂N HP N OH OH OH OH GA OH

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The enzyme dihydroneopterin aldolase (DHNA) is found in the metabolic pathway leading to folic acid. The enzyme catalyzes the reaction below, the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropeterin (HP) and glycoaldehyde (GA), the third step in the biosynthetic path to folic acid. The enzyme also catalyzes the epimerization of 7,8-dihydroneopterin to 7,8-dihydro-L-monopterin (DHMP). Provide a chemical mechanism that can account for the formation of both of these products. Be sure to show the involvement of enzyme residues that might facilitate each step in the mechanism. HN H₂N OH DHNP OH OH HN H₂N DHMP HN H₂N HP OH ÕH OH OH + GA OH
Transcribed Image Text:The enzyme dihydroneopterin aldolase (DHNA) is found in the metabolic pathway leading to folic acid. The enzyme catalyzes the reaction below, the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropeterin (HP) and glycoaldehyde (GA), the third step in the biosynthetic path to folic acid. The enzyme also catalyzes the epimerization of 7,8-dihydroneopterin to 7,8-dihydro-L-monopterin (DHMP). Provide a chemical mechanism that can account for the formation of both of these products. Be sure to show the involvement of enzyme residues that might facilitate each step in the mechanism. HN H₂N OH DHNP OH OH HN H₂N DHMP HN H₂N HP OH ÕH OH OH + GA OH
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