10. A drug requires freezing storage conditions (-20 °C). Based on the following data, indicate the shelf life (years) of the drug under these conditions. Temperature (K) Rate Constant (h°¹) 323 298 0.5 0.1 Dosage Form Design 1 Workshop/Tutorial 1 (cont.) 11. Cytosar (Upjohn) is most stable near neutral pH (6.9). Using the following data predict the number of hours which this solution would maintain 80% potency at 30 °C. Temperature °C 10 70 60 60 55 47 47 K k (h) 0.872 x 103 0.390 x 103 0.273 x 10-3 0.153 x 103
10. A drug requires freezing storage conditions (-20 °C). Based on the following data, indicate the shelf life (years) of the drug under these conditions. Temperature (K) Rate Constant (h°¹) 323 298 0.5 0.1 Dosage Form Design 1 Workshop/Tutorial 1 (cont.) 11. Cytosar (Upjohn) is most stable near neutral pH (6.9). Using the following data predict the number of hours which this solution would maintain 80% potency at 30 °C. Temperature °C 10 70 60 60 55 47 47 K k (h) 0.872 x 103 0.390 x 103 0.273 x 10-3 0.153 x 103
Chapter13: Dimensional Analysis/units Conversion
Section: Chapter Questions
Problem 1.3P
Related questions
Question
I’m finding it a bit difficult to understand the Arrhenius equation and how shelf life relates to pH and temperature. Also in the question that says ‘this solution maintains 80% potency at 30C’, am I correct in thinking the formula would be:
t = ln(0.8)/ -k

Transcribed Image Text:10. A drug requires freezing storage conditions (-20 °C). Based on the following data, indicate the shelf life
(years) of the drug under these conditions.
Temperature (K)
Rate Constant (h°¹)
323
298
0.5
0.1

Transcribed Image Text:Dosage Form Design 1
Workshop/Tutorial 1 (cont.)
11. Cytosar (Upjohn) is most stable near neutral pH (6.9). Using the following data predict the
number of hours which this solution would maintain 80% potency at 30 °C.
Temperature
°C
10
70
60
60
55
47
47
K
k (h)
0.872 x 103
0.390 x 103
0.273 x 10-3
0.153 x 103
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