Deletions in bacterial chromosomes give the following data:Region of deletionAlGene A activity+++A2АЗA4AS+++(i)Where is the gene located? Explain your answer.Name the scientific term that describes the appearance of a recessive phenotype dueto deletion of dominant gene.(ii)(iii) The phenotypic consequences of deletion depend on two factors. What are they?Give one example of human genetic disorder caused by chromosomal deletion byindicating the region of deletion in chromosome.(iv)

The gene is located in A3 region. Because deletion of the A3 region leads to the least activity of…

Answered: Deletions in bacterial chromosomes give…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Below is shown a recombination intermediate between two non-sister chromatids (both strands of the double helix are shown for each chromatid with one chromatid shown in grey, the other in black). A a 000 00 1 ↓ 1 and 2 1 and 4 2 and 4 1 and 3 3 and 4 2→ 2 ↑ 1 3 ↓ 4-→ - ↑ 3 -4 B At the two Holliday junctions shown, breakage and and rejoining of DNA strands are needed to allow resolution of the junctions and subsequent separation of chromatids at the end of meiosis I. Which combination of breakage sites (numbered arrows) will result in creation of the recombinant chromatids, Ab and aB? b
Among the mechanisms of gene transfer in bacteria, which one is capable of transferring the largest chromosome segment from donor to recipient? Which process generally transfers the smallest donor segements to the recipient? Explain your reasoning for both asnwers.
When considering the cause of the disease in a patient who is the child of an inbred couple, it was found that 4 enzymes in the lysosome were inactivated. When comparing the amino acid sequences of these four enzymes with the wild-type enzyme, no difference was found in the number and arrangement of amino acids. Given mutations that may be the cause of the patient's disease above.
Select the statements below that are TRUE. Select 4 correct answer(s) Question 14 options: A) Mutations are induced to occur in response to a selective pressure. B) Crossover suppression occurs when no recombinant progeny are observed between two genes located within a homozygous paracentric inversion. C) The ends of each chromosome are replicated by an RNA-protein complex called telomerase. D) When a mismatched base pair occurs during DNA replication, mismatch repair corrects the mismatch by replacing the nucleotide on the template strand. E) Mutations occur spontaneously and so may be pre-existing in a population when a selective pressure arises. F) When two genes are linked, the frequency of recombinant types exceeds the frequency of parental types. G) The choice…
An STR on chromosome 5 is very closely linked to a gene involved in a dominant metabolism disorder (one one copy of the mutation causes the disease). There are four different alleles of the STR (Q, B, S, and L), each with different numbers of GATCTCG repeats. The S allele has 2 repeats, the B allele has 7 repeats, the Q allele has 10 repeats, and the L allele has 5 repeats. Part 1 Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Move the letter of each allele to its correct position at the left of Lane 1 to indicate where each allele runs on the gel. 0000 Gabriel Andre Lane 1 O Maria Andre Maria Juliana B L Part 2 Andre and Maria are the parents in this family; all others shown on the gel are children. Daughter Juliana is born with the metabolism disorder, but daughter Camila does not have the disorder. Assuming no recombination between the STR…
Using the conventions of Figure 4-15, draw parents andprogeny classes from a crossP M′′′/p M′ × p M′/p M′′′′
number 32
The following gene arrangements in a particular chromosome are found in different geographic regions. The changes in sequence were due to sequential inversions. KLMNOP NOPKML KPONML NOMKPL Assuming that the arrangement in “a” is the original arrangement, in what sequence did the various inversion types arise?
Consider the arrangement of the following four normal chromosomes from some hypothetical organism where, denotes the location of the centromere: A BCDEF GHIJ KLMNO For the following question indicate what type of chromosomal mutation has occurred. GHIJ KNMLO O a. Robertsonian translocation O b. Reciprocal translocation O c. Pericentric inversion PQ RSTU V WXYZ O d. Segmental duplication Oe. Paracentric inversion
6. A diploid strain of yeast was made by mating a haploidstrain with a genotype w−, x−, y−, and z− with a haploidstrain of opposite mating type that is wild type for thesefour genes. The diploid strain was phenotypically wildtype. Four different X-ray-induced diploid mutantswith the following phenotypes were produced fromthis diploid yeast strain. Assume a single new mutation is present in each strain.Strain 1 w− x+ y− z+Strain 2 w+ x− y− z−Strain 3 w− x+ y− z−Strain 4 w− x+ y+ z+When these mutant diploid strains of yeast go throughmeiosis, each ascus is found to contain only two viablehaploid spores.a. What kind of mutations were induced by X-rays tomake the listed diploid strains?b. Why did two spores in each ascus die?
Please consider the figure below, parts A and B. A В Gene B Gene C Gene B Normal Gene A Chromosome 12 Normal Chromosome 1 Please consider figure A. a. Do these chromosomes come from a dividing or non-dividing cell? Give a reason for your answer. b. How many molecules of double stranded DNA will be present at anaphase I of a cell from this organism? Please consider figure B. A potentially carcinogenic mutation occurred on one of the chromosomes. The gene affected by the mutation codes for a protein involved in the repair of DNA damage. c. What is the correct term used to describe this chromosomal mutation? d. In terms of the development of cancer, is this a dominant or recessive mutation? e. What is the consequence of this mutation if it occurs during meiosis and is inherited by the offspring? Explain your answer in terms of the function of the protein.
The completely synthetic yeast chromosome Syn IIIcontains a loxP site in the 3′ UTR of every gene thatis potentially nonessential to yeast survival. As youwill recall from Chapter 6, loxP sites are targets ofsite-specific recombination. The researchers who constructed Syn III included these loxP sites as a way to“scramble” the chromosome, meaning that parts ofthe chromosome could easily be deleted or rearranged.The goal of these investigations is to drive the evolution of Syn III so as to define a minimal genome thatcan support the life of this organism. Outline the experiment the researchers would do to scramble Syn IIIin order to define a minimal genome.

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