46. A 1-month-old boy with X-linked severe combined immunodeficiency is enrolled in a gene therapy trial. Bone marrow stem cells are extracted from the patient and are treated ex vivo with a retrovirusexpressing the wild-type gene. Although the patient initially responds well, 30 months after treatment he develops a form of T-lymphocyte leukemia. Molecular studies show that the T lymphocytes aremonoclonal. Which of the following viral processes is the most likely cause of the leukemia in this patient?A) Deactivation of the p53 tumor suppressor geneB) Generation of the Philadelphia (Ph¹) chromosomeC) Integration adjacent to an oncogeneD) Phosphorylation of pRBE) Reverse transcription of PTEN

A) Deactivation of the p53 tumor suppressor gene:This option is incorrect because p53 is a tumor…

Answered: Deactivation of the p53 tumor…

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Deactivation of the p53 tumor suppressor gene Generation of the Philadelphia (Ph¹) chromosome Integration adjacent to an oncogene Phosphorylation of pRB Reverse transcription of PTEN