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Deactivation of the p53 tumor suppressor gene Generation of the Philadelphia (Ph¹) chromosome Integration adjacent to an oncogene Phosphorylation of pRB Reverse transcription of PTEN

Deactivation of the p53 tumor suppressor gene Generation of the Philadelphia (Ph¹) chromosome Integration adjacent to an oncogene Phosphorylation of pRB Reverse transcription of PTEN

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46. A 1-month-old boy with X-linked severe combined immunodeficiency is enrolled in a gene therapy trial. Bone marrow stem cells are extracted from the patient and are treated ex vivo with a retrovirus expressing the wild-type gene. Although the patient initially responds well, 30 months after treatment he develops a form of T-lymphocyte leukemia. Molecular studies show that the T lymphocytes are monoclonal. Which of the following viral processes is the most likely cause of the leukemia in this patient? A) Deactivation of the p53 tumor suppressor gene B) Generation of the Philadelphia (Ph¹) chromosome C) Integration adjacent to an oncogene D) Phosphorylation of pRB E) Reverse transcription of PTEN
Transcribed Image Text:46. A 1-month-old boy with X-linked severe combined immunodeficiency is enrolled in a gene therapy trial. Bone marrow stem cells are extracted from the patient and are treated ex vivo with a retrovirus expressing the wild-type gene. Although the patient initially responds well, 30 months after treatment he develops a form of T-lymphocyte leukemia. Molecular studies show that the T lymphocytes are monoclonal. Which of the following viral processes is the most likely cause of the leukemia in this patient? A) Deactivation of the p53 tumor suppressor gene B) Generation of the Philadelphia (Ph¹) chromosome C) Integration adjacent to an oncogene D) Phosphorylation of pRB E) Reverse transcription of PTEN
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