Close contact. Examination of the structure of DNA polymerasesbound to nucleotide analogs reveals that conserved residues comewithin van der Waals contact of C-2'C-2' of the bound nucleotide.What is the potential significance of this interaction?

DNA polymerases are the enzyme that replicates DNA in cells. DNA polymerase can not create new…

Answered: Close contact. Examination of the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Biological Macromolecules Understanding that DNA replication is semiconservative -pil... 0/5 Julianna The coding (sense) strands of two complete (double-stranded) DNA molecules have the base sequences shown in the table below. Two replication experiments are done with each molecule: 1. In Experiment #1, samples of each DNA molecule are incubated with radioactive adenine, along with appropriate replication enzymes, ATP, adenine, thymine, and cytosine. Experiment #1 is stopped when each DNA molecule has replicated once. 2. In Experiment # 2, all the DNA molecules from #1 are purified, and then incubated with with a similar reaction mixture is used this time. Experiment #2 is stopped when each DNA molecule has replicated one more time. - ? except non-radioactive adenine olo Predict the percentage of DNA in each sample that is radioactive after each experiment. Round your answers to the nearest percent. DNA coding strand sequence 5'- TGGCTG-3' 5'- ACGGGC-3' % of DNA radioactive after...…
DNA Stability/Chapter 4 A solution of DNA contains two different DNA molecules. Molecule 1 is 500 base pairs and contains 100 A’s. Molecule 2 is 500 base pairs and contains 300 A’s. (1) How many AT base pairs and GC base pairs is in each DNA molecule? (2) How many, G’s, A’s, T’s and C’s are in each molecule? (3) Draw one figure that shows the relative melting temperature of the two DNA molecules.
5’-CCTAGACCATAACAT-3’ What happens to the amino acid sequence above as a result of each of the following mutations in the DNA: Substitution of A with T at position 4? Addition of T between positions 8 and 9? Substitution of A with T at position 11? Deletion of A at position 12? Substitution of C with T at position 7? State the type of mutation for each of the base changes indicated.
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4A. In the human gene for the beta chain of haemoglobin (the oxygen-carrying protein in the red blood cells), the first 30 nucleotides in the amino-acid-coding region is represented by the sequence: 3'-TACCACGTGGACTGAGGACTCCTCTTCAGA-5'. What is the sequence of the partner strand?

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Close contact. Examination of the structure of DNA polymerases bound to nucleotide analogs reveals that conserved residues come within van der Waals contact of C-2'C-2' of the bound nucleotide. What is the potential significance of this interaction?