11. The SARS (SARS CoV-1) virus and Covid19 (SARS-CoV-2) virus both bind to the angiotensin-converting enzyme (ACE2) receptor, but with different affinities. The Spike protein of SARS has a Kd of 330NM and Covid19 has 15nM. a. On the same graph, draw a "conceptual" binding curve for both viruses' spike proteins and the ACE 2 receptor. Label the graph appropriately.) b. What is your interpretation of the graph in (a)a, c. The new variant of Covid19, first identified in England is up to 70% more infectious than Covid19. What would you anticipate is happening to the Kd for this new variant?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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11. The SARS (SARS CoV-1) virus and Covid19 (SARS-CoV-2) virus both bind to the
angiotensin-converting enzyme (ACE2) receptor, but with different affinities. The Spike protein
of SARS has a Kd of 330NM and Covid19 has 15nM.
a. On the same graph, draw a "conceptual" binding curve for both viruses' spike proteins and
the ACE 2 receptor. Label the graph appropriately.)
b. What is your interpretation of the graph in (a)a,
c. The new variant of Covid19, first identified in England is up to 70% more infectious
than Covid19. What would you anticipate is happening to the Kd for this new
variant?
Transcribed Image Text:11. The SARS (SARS CoV-1) virus and Covid19 (SARS-CoV-2) virus both bind to the angiotensin-converting enzyme (ACE2) receptor, but with different affinities. The Spike protein of SARS has a Kd of 330NM and Covid19 has 15nM. a. On the same graph, draw a "conceptual" binding curve for both viruses' spike proteins and the ACE 2 receptor. Label the graph appropriately.) b. What is your interpretation of the graph in (a)a, c. The new variant of Covid19, first identified in England is up to 70% more infectious than Covid19. What would you anticipate is happening to the Kd for this new variant?
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