3 Infliximab is a chimeric mouse-human monoclonal antibody generated against the inflammatory cytokine TNF-a. Adalimumab is a fully humanized anti-TNF-a antibody. How might some patients become resistant to infliximab therapy and yet still respond to adalimumab?

3 Infliximab is a chimeric mouse-human monoclonal antibody generated against the inflammatory cytokine TNF-a. Adalimumab is a fully humanized anti-TNF-a antibody. How might some patients become resistant to infliximab therapy and yet still respond to adalimumab?

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter45: Defenses Against Disease

Section: Chapter Questions

Problem 13TYK

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Concept explainers

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.

Question

3 Infliximab is a chimeric mouse-human monoclonal antibody generated against
the inflammatory cytokine TNF-a. Adalimumab is a fully humanized anti-TNF-a
antibody. How might some patients become resistant to infliximab therapy and yet
still respond to adalimumab?

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