4. You are to choose the members of an expedition that will climb several high mour Each applicant for one of the positions is a heterozygote for an abnormal hemoglo Person A: Hb Albany: a methionine has been substituted for Lys 82 in the B-subur Person B: Hb Cowtown: a leucine has been substituted for His 146 in the B-subuni
4. You are to choose the members of an expedition that will climb several high mour Each applicant for one of the positions is a heterozygote for an abnormal hemoglo Person A: Hb Albany: a methionine has been substituted for Lys 82 in the B-subur Person B: Hb Cowtown: a leucine has been substituted for His 146 in the B-subuni
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:4. You are to choose the members of an expedition that will climb several high mountains.
Each applicant for one of the positions is a heterozygote for an abnormal hemoglobin:
Person A: Hb Albany: a methionine has been substituted for Lys 82 in the B-subunit.
Person B: Hb Cowtown: a leucine has been substituted for His 146 in the B-subunit.
Person C: Hb Flagstaff: an isoleucine has been substituted for Val 1 in the B-subunit.

Transcribed Image Text:and the KİNG exercises. Assuming that each of these candidates is equal in ability at low
altitude, which one would you choose for the expedition? To answer this question, determine
how the substituted amino acid affects the structure and function of each abnormal
hemoglobin, and describe the physiological effect. Focus on the stabilization of the T versus
R state of hemoglobin, and the consequent physiological changes that might occur at high
altitude. Keep your answers brief.
Person A
Person B
Person C
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