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(a) dues in the polypeptide. Place the label or an arrow on the Ca atom of both residues. Label the N-terminal and the C-terminal amino acid resi- Identify each amino acid residue and give the sequence of (b) ( the linker. Write the sequence according to both three-letter and one- letter abbreviations. H2N (c) ( ations and in parentheses indicate the chirality, L or D, for each resi- due. ) Write the sequence again according to three-letter abbrevi-

(a) dues in the polypeptide. Place the label or an arrow on the Ca atom of both residues. Label the N-terminal and the C-terminal amino acid resi- Identify each amino acid residue and give the sequence of (b) ( the linker. Write the sequence according to both three-letter and one- letter abbreviations. H2N (c) ( ations and in parentheses indicate the chirality, L or D, for each resi- due. ) Write the sequence again according to three-letter abbrevi-

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. A variety of organic chelating ligands have been synthesized to tightly coordinate radioactive metal cations to identify and treat malig- nancies by coupling the metal complex to a polypeptide linker attached to a monoclonal antibody that binds specifically to a cell surface re- ceptor. One such metal complex is illustrated in the diagram on the right. The radioactive Cu-64 cation is tightly coordinated by the che- lating ligand that is, in turn, conjugated to a peptide linker attached to a monoclonal antibody. (The antibody is not shown in this diagram.) When coupled to a specifically designed monoclonal antibody, the complex binds specifically to somatostatin receptors that are ex- pressed on the surface of neuroendocrine tumors. Subsequently the entire complex with the receptor is internalized, i.e., passed into the cytoplasm, where the radioactive metal cation kills the malignant cell. CH3 HN NHNH HN NHNH HN НО НО NH HN HN HO S-S NH (a) dues in the polypeptide. Place the label or an arrow on the Ca atom of both residues. Label the N-terminal and the C-terminal amino acid resi- NH HN -NH HN- Identify each amino acid residue and give the sequence of (b) ( the linker. Write the sequence according to both three-letter and one- letter abbreviations. H2N OH NH ) Write the sequence again according to three-letter abbrevi- (c) ( ations and in parentheses indicate the chirality, L or D, for each resi- due.
Transcribed Image Text:1. A variety of organic chelating ligands have been synthesized to tightly coordinate radioactive metal cations to identify and treat malig- nancies by coupling the metal complex to a polypeptide linker attached to a monoclonal antibody that binds specifically to a cell surface re- ceptor. One such metal complex is illustrated in the diagram on the right. The radioactive Cu-64 cation is tightly coordinated by the che- lating ligand that is, in turn, conjugated to a peptide linker attached to a monoclonal antibody. (The antibody is not shown in this diagram.) When coupled to a specifically designed monoclonal antibody, the complex binds specifically to somatostatin receptors that are ex- pressed on the surface of neuroendocrine tumors. Subsequently the entire complex with the receptor is internalized, i.e., passed into the cytoplasm, where the radioactive metal cation kills the malignant cell. CH3 HN NHNH HN NHNH HN НО НО NH HN HN HO S-S NH (a) dues in the polypeptide. Place the label or an arrow on the Ca atom of both residues. Label the N-terminal and the C-terminal amino acid resi- NH HN -NH HN- Identify each amino acid residue and give the sequence of (b) ( the linker. Write the sequence according to both three-letter and one- letter abbreviations. H2N OH NH ) Write the sequence again according to three-letter abbrevi- (c) ( ations and in parentheses indicate the chirality, L or D, for each resi- due.
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