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A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in a change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction O since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction O the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease

A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in a change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction O since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction O the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in a change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease
Transcribed Image Text:A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in a change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease
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