Another Test for Cocaine AddictionAn experiment was designed on helping cocaine addicts break the cocaine addiction, in which cocaine addicts were randomized to take desipramine, lithium, or a placebo. The results (relapse or no relapse after six weeks) are summarized in the table below.   Relapse No relapse Total Desipramine 10 14 24 Lithium 18 6 24 Placebo 20 4 24 Total 48 24 72 (a) From the table, we calculate a χ2 statistic of 10.5 and use a χ2 distribution to calculate a p-value of 0.005 using these data, but we also could have used a randomization distribution. How would you use cards to generate a randomization sample? What would you write on the cards, how many cards would there be of each type, and what would you do with the cards? (Open-ended, typed answer)   (b) If you generated 1000 randomization samples according to your procedure from part (a) and calculated the χ2 statistic for each, approximately how many of these statistics do you expect would be greater than or equal to the χ2 statistic of 10.5 found using the original sample?

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Another Test for Cocaine Addiction

An experiment was designed on helping cocaine addicts break the cocaine addiction, in which cocaine addicts were randomized to take desipramine, lithium, or a placebo. The results (relapse or no relapse after six weeks) are summarized in the table below.


 
Relapse
No relapse
Total
Desipramine
10
14
24
Lithium
18
6
24
Placebo
20
4
24
Total
48
24
72

(a) From the table, we calculate a χ2 statistic of 10.5 and use a χ2 distribution to calculate a p-value of 0.005 using these data, but we also could have used a randomization distribution. How would you use cards to generate a randomization sample? What would you write on the cards, how many cards would there be of each type, and what would you do with the cards? (Open-ended, typed answer)
 
(b) If you generated 1000 randomization samples according to your procedure from part (a) and calculated the χ2 statistic for each, approximately how many of these statistics do you expect would be greater than or equal to the χ2 statistic of 10.5 found using the original sample?
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