An experiment was conducted with two groups of genetically identical female agouti mice (Avy/a) that were mated with normal (a/a) male mice . Both female groups ate lab chow with bisphenol A (BPA) (50mg/Kg). (BPA, used in the manufacture of polycarbonate plastics, has estrogenic effects that include decreased CpG methylation.) The lab chow of one group was supplemented with methyl donors (e.g., folate, choline, and vitamin B12). The effects of BPA were abolished in the Avya offspring of the mice fed with the methyl donor–supplemented chow (i.e., the coat color distribution observed was shifted toward brown). Explain.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
An experiment was conducted with two groups of genetically identical female agouti mice
(Avy/a) that were mated with normal (a/a) male mice . Both female groups ate lab chow with
bisphenol A (BPA) (50mg/Kg). (BPA, used in the manufacture of polycarbonate plastics, has
estrogenic effects that include decreased CpG methylation.) The lab chow of one group was
supplemented with methyl donors (e.g., folate, choline, and vitamin B12). The effects of BPA
were abolished in the Avya offspring of the mice fed with the methyl donor–supplemented
chow (i.e., the coat color distribution observed was shifted toward brown). Explain.
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