first codon nucleotidesecond codon nucleotideGCysCysUU PhePhe SerLeuSerLeuSerC LeuProLeuProLeuProLeuProA lleThrlleThrlleThrMet ThrAlaAlaAlaAlaG ValValValValсASer TyrTyrc. template[Select]STOP Trpd. template[ Select]HisHisGinGinSTOP STOP AAsnAsnLysLysAspAspGluGluArgArgArgArgSerSerArgArgGlyGlyGlyUGlyCAGUCAGUAGSCAGсссАсАA phenotypically normal person has these threenucleotides 3'-GCC-5' on the DNA template strandwithin an important gene.a. Which amino acid does this code for?[Select]third codon nucleotideIdentify the effect of the following point mutations (givenas the DNA template strand again).b. template3'-GCG-5' This mutation results indifferent amino acids from this point on (a frameshiftmutation).3'-ACT-5' This mutation results in3'-GGT-5' This mutation results in

Name: first codon nucleotidesecond codon nucleotideGCysCysUU PhePhe SerLeuS
Uploaded: 2024-03-20T06:42:41.000Z
Channel: Bartleby
Description: first codon nucleotidesecond codon nucleotideGCysCysUU PhePhe SerLeuSerLeuSerC LeuProLeuProLeuProLeuProA lleThrlleThrlleThrMet ThrAlaAlaAlaAlaG ValValValValсASer TyrTyrc. template[Select]STOP Trpd. template[ Select]HisHisGinGinSTOP STOP AAsnAsnLysLy

Introduction Mutation is a sudden heritable change in our DNA or genetic material. Mutation can occur in somatic cell or germ cell. Somatic mutation can not pass from one generation to another. But germline mutation can pass from one generation to another. Explanation DNA is a self replicating molecule. Transcription is a process by which mRNA is produced from DNA and translation is a process by which protein is produced from mRNA. A codon is a DNA or mRNA sequence containing three nitrogenous bases. DNA contains total 4 nitrogenous bases, A, T, G and C. These 4 nitrogenous bases give rise to total 64 codons (43). Among these 64 codon 3 are stop codons and 61 codons code for 20 different amino acids present in our body. As no of codon is more than no of amino acids, therefore one amino acid can have more than one codon but one codon can not have than one amino acids. Mutation is a sudden heritable change in our DNA or genetic material. Mutation can occur in somatic cell or germ cell. a) Given, a phenotypically normal person has DNA sequence 3'to 5' DNA sequence 3' -GCC- 5' 5'to 3' DNA sequence 5'- CGG-3' mRNA sequence 5'- CGG -3' amino acid: Arginine c) 3'to 5' DNA sequence : 3'-GCC- 5' After mutation the DNA strand : 3'-ACT- 5' 5'to 3' DNA sequence : 5'- TGA-3' mRNA: 5'- UGA -3' amino acid: It is a stop codon. Does not code for any amino acid. Here G is changed to A and C is changed to T. Here purine changes to another purines (G → A) and pyrimidine changes to another pyrimidine (C → T). That means it is a transition mutation. But in this point mutation the codon of the changed DNA sequence (UGA) gives rise to stop codon. Does not code for any amino acid. Therefore it is a nonsense codon. d) 3'to 5' DNA sequence : 3'-GCC- 5' After mutation the DNA strand : 3'-GGT-5' 5'to 3' DNA sequence : 5'-CCA-3' mRNA : 5'- CCA-3' amino acid: Proline Here C is changed to G, that means pyrimidine changes to purine. That is transversion and C is changed to T, that means pyrimidine changes to another pyrimidine. It is a transition mutation. This point mutation which results into synthesis of another amino acid (proline). That means it is missense mutation.