A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle checkpoint inhibitor B) Loss of expression of a growth factor that promotes cell cycle entry C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry D) Overexpression of a DNA damage repair enzyme E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin   B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle? A) They promote the G1 to S checkpoint B) They normally inhibit M phase from being completed C) They form the mitotic spindle E) They mediate DNA replication F) They form the cleavage furrow during cytokinesis

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: You add a chemical to a cell that prevents all of the chromatin from uncoiling so that the…

A: Transcription is the process of formation of messenger RNA using DNA as a template and DNA dependent…

Q: Personalized cancer treatments involve identifying specific pathways in an individual tumor and…

A: Introduction Cancer is defined as a condition which is characterised by uncontrolled mitosis. In…

Q: rms of the cell cycle, what would happen if there was a defect in the Rb prote made it unable to…

A: Rb protein is a tumor suppressor protein that is it suppresses the tumor from growing. Hence Rb…

Q: The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene…

A: An oncogene is a type of gene that is responsible for causing the cells to divide uncontrollably and…

Q: Which of the following decreases during tumor progression? 1) angiogenesis 2) mitosis 3) meiosis 4)…

A: An irreversible change in the tumor's features that represents the sequential development of a…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: The rb gene encodes a protein that inhibits E2F, a transcriptionfactor that activates several genes…

A: Abnormal and unnecessary growth of cells termed cancer. Mutations in DNA causes cancer. In the…

Q: Why is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene…

A: Uncontrolled cell division in the cells may result into the tumor formation. Sometimes the cells may…

Q: Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb?…

A: Cell division is a process through which a cell produces two identical daughter cells. Cell division…

Q: How can researchers pinpoint the particular driver mutations most responsible for the cancer…

A: The development of cancer is an evolutionary process at the cellular level. Several mutations…

Q: Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell…

A: Need to find all the options that produce uncontrollable cell division  and to increase chance of…

Q: a. What are the three categories of genes mutated in cancer cells? What is the effect of mutation of…

A: 1.  a. What are the three categories of genes mutated in cancer cells? What is the effect of…

Q: The drug vincristine, which prevents polymerization of tubulin, is used as a chemotherapeutic agent…

A: Mechanism of actions of drug vincristine in cancer treatment.

Q: Explain why IC3 is able to stop cancerous cells from dividing ?

A: Tumor-suppressor proteins are those proteins that normally act to stop abnormal cell growth. But…

Q: You are studying cancer progression in mice. Your results show the following pathway in which two…

A: From the given data the observations made are: The experiment is conducted in a nutrient-enriched…

Q: What role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with…

A: The cell cycle is an ordered series of events by which a cell duplicates its genome and divides into…

Q: In a wild-type cell, the function of a protein encoded by a tumor-suppressor gene is to cause a cell…

A: When a cell grows and divides uncontrolled it leads to the formation of an irregular mass of cells…

Q: Why would elevated levels of PSA be suggestive of prostate cancer given what you know about cancer?…

A: The prostate gland is situated below the urinary bladder and is responsible for the production of…

Q: A. Which genes could be used to monitor the process of the disease? B.  If you worked for a drug…

A: By collecting mRNA samples from patients over the course of four phases, we may analyze the…

Q: Rb and Ink4 Cdk inhibitors are able to slow cell cycle progression. : a) True b) False

A: The cell cycle is a series of events that occur in a cell leading to its division and duplication.…

Q: 1. Explain BRIEFLY whether each of the following conditions will increase or decrease the chance of…

A: Note:- Since you have posted a question with multiple subparts, so we will be solving the first…

Q: Which of the following statements are correct about cytoplasmic signaling in cancer cells? Multiple…

A: Metastasis is a significant cause of mortality worldwide. Cancer cells acquire genetic alterations…

Q: What would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53…

A: p53 is known as a cellular tumor antigen 53 is a protein found in vertebrates that is responsible…

Q: There are many compounds that have been advertised to reduce or delay aging. Resveratrol is a…

A: Resveratrol is a compound found in red wine and other plants that has been shown to have a variety…

Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…

A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…

Q: is a normal cellular gene that through a A an oncogene. OA) proto-oncogene...loss-of-function OB)…

A: An oncogene is a cancer-causing gene that has been mutated. A proto-oncogene is a type of oncogene…

Q: 1). Tumor suppressor proteins monitor DNA and detect damage. Some cancers evade this detection by…

A: Tumor suppressor proteins helps to control cell growth and activated in response to DNA damage and…

Q: Describe three changes in cell cycle control and regulatory proteins that lead to cancer.

A: Key references:Boutelle, A. M., & Attardi, L. D. (2021). p53 and tumor suppression: it takes a…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.