What would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53 functions?

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: How can a defect in p53 gene contribute to cancer development?

A: Cancer is an abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: What are the normal functions of the BRCA1 tumor suppressor gene?

A: The BRCA1 gene codes for the protein that causes breast cancer type 1. BRCA1 is a human tumour…

Q: Compare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes.…

A: Genetic changes are the primary cause of cancer, an incredibly complicated and multidimensional…

Q: Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components…

A: There are two types of cell division.They are Mitosis and Meiosis. Most of the times,the type of…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: The normal function of one tumor-suppressor gene acting at the G1 checkpoint is to prevent cells…

A: The cell cycle consists of four steps- G1, S, G2, and M phases. In the G1 phase, the cell increases…

Q: What role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with…

A: The cell cycle is an ordered series of events by which a cell duplicates its genome and divides into…

Q: How can a mutation in a tumor-suppressor gene contribute to the development of cancer?

A: Tumor-suppressor genes are like any other normal genes whose functions include slowing down cell…

Q: illustrate some of the molecular mechanisms leading from loss-of-function mutations in…

A: Tumor suppressing genes also known as Anti - oncogenes are the  regulatory genes which regulates…

Q: Why would elevated levels of PSA be suggestive of prostate cancer given what you know about cancer?…

A: The prostate gland is situated below the urinary bladder and is responsible for the production of…

Q: What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to…

A: Cancer is group of diseases which are characterized by abnormal and unstoppable growth of cell and…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Excessive angiogenesis and reduced apoptosis are two of the six characteristics that define…

A: Angiogenesis:  Angiogenesis refers to the process of the growth and development of new blood vessels…

Q: Why would a mutation in BRCA1 be considered a driver mutation?  b. Based on what you’ve learned…

A: In this question, we  have to answer 'BRCA gene consider as driver mutation and ATM consider as a…

Q: xplain the molecular mechanisms of cancers caused by a P53 gene mutation.

A: cancer may be a disease during which a number of the body’s cells grow uncontrollably and spread to…

Q: Explain the difference between proto-oncogene and tumor suppressor mutations in terms of its…

A: Cancer is a medical condition that is characterized by the growth of tumors in the body of an…

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.