Answered: Normal p53 is a tumor suppressor gene,…

Normal p53 is a tumor suppressor gene, when mutated it loses this function. Explain how a tissue expressing normal p53 would lose control and have over-proliferation of the cells based on p53 levels.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section12.10: Genomics, Epigenetics,and Cancer

Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...

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Concept explainers

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.

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Normal p53 is a tumor suppressor gene, when mutated it loses this function. Explain how a tissue expressing normal p53 would lose control and have over-proliferation of the cells based on p53 levels.

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