3. Study the image below to answer the questions.ERK2ERK2-P2ABC-termN-termB1LOC-termN-termaL16B1 2LO828463Ribbon-anoL16Ribbon-L16898788B6C-loop Pe* PY185FLipL16-LipLoop199-20aL12aFMKIIL14 2L14ERK2 – green/gold-ERK2-P2 – blue/redA) What type of regulatory enzyme is this?B) In what general type of cellular pathway does this enzyme participate?C) Which form of the enzyme is active – ERK2 or ERK2-P2?D) What does "P2" stand for?E) Ultimately (meaning "finally") what is the ultimate effect on cellular metabolism due to activation of thisenzyme?

Answered: A) What type of regulatory enzyme is…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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In the above diagram, the N-terminal domain(residues 1–109 and 320–358) is made up of $β$ strands (green) largely and two helices, $α L 16$ (magenta) and C(blue).

The C-terminal domain (residues 110-319) is mostly helical (blue), has phosphorylation lip (red) and the MAP kinase insertion (magenta).

Also, the side chains Thr-183, p-Tyr-183, Tyr-185 and p-Tyr-185 can be seen.

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