Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
In hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between ß-chains and x-chains

In hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between ß-chains and x-chains

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
In hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization O B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between B-chains and x-chains OD) Changes in binding of 2,3-bisphosphoglycerate
Transcribed Image Text:In hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization O B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between B-chains and x-chains OD) Changes in binding of 2,3-bisphosphoglycerate
Expert Solution
Step 1

Sickle cell anemia is a genetic disease that results in the formation of the sickle shape of RBCs. The sickle shape of RBCs is a result of the precipitation of mutated beta-globin chains in sickle cell anemia patients. The precipitation of hemoglobin in the deoxygenated state is a result of the mutation of valine from aspartic acid in the beta-globin chain. 

steps

Step by step

Solved in 3 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS