A researcher studying epigenetic changes induced by exercise had participants pedal a stationary bicycle with only one leg for 45 minutes a day, 4 times a week for 3 months. They then took muscle biopsies from both legs (the one that exercised and the one that did not) and compared DNA to look for epigenetic changes induced by exercise. They found over 5,000 sites on the genome where methylation patterns differed between the DNA isolated from the exercised leg and DNA isolated from the non-exercised leg. A. How would you predict these changes would affect transcription and translation? Is there other information you need to know to feel confident in your prediction? B. Would these changes be passed down to the participants' offspring? Why or why not? C. Why did all participants exercise only one leg rather than having two groups- one who exercised and one who did not?
A researcher studying epigenetic changes induced by exercise had participants pedal a stationary bicycle with only one leg for 45 minutes a day, 4 times a week for 3 months. They then took muscle biopsies from both legs (the one that exercised and the one that did not) and compared DNA to look for epigenetic changes induced by exercise. They found over 5,000 sites on the genome where methylation patterns differed between the DNA isolated from the exercised leg and DNA isolated from the non-exercised leg.
A. How would you predict these changes would affect transcription and translation? Is there other information you need to know to feel confident in your prediction?
B. Would these changes be passed down to the participants' offspring? Why or why not?
C. Why did all participants exercise only one leg rather than having two groups- one who exercised and one who did not?
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