A gut epithelial cell line that has been genetically engineered to express acommon cystic-fibrosis-causing CFTR mutation is accidentally cross-contaminated with cholera bacteria from another experiment. Given whatyou know of CFTR's role in both disease states, what is a likely outcome?Cl- rushes out of the cells.O CI- rushes into the cells.O CI- levels are unchanged but Na+ is driven out of the cells.CI- levels in the cells are unaffected.

Cholera is a bacterial disease characterized by diarrhoea and dehydration. The disease is caused by…

Answered: A gut epithelial cell line that has…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

What is the effect of pertussis toxin on G proteins? Inhibits activation of Gαi leading to suppression of adenylyl cyclase. Stimulates activation of Gαi leading to activation of adenylyl cyclase. Stimulates activation of Gαs leading to activation of adenylyl cyclase. Inhibits activation of Gαi leading to activation of adenylyl cyclase.
VEGF is synthetized in cancer cell to promote angiogenesis. Which sentence is correct? Polypeptide chain is synthesized on ribosomes attached to the ER (rough ER), and translocated through the membrane to the lumen by protein translocator, which is constantly active; mature VEGF chain is released to the lumen through signal peptidase cleavage. Polypeptide chain is synthesized on ribosomes attached to the ER (rough ER), and translocated through the membrane to the lumen by protein translocator, which is activated by start-transfer sequence; mature VEGF chain is . Polypeptide chain is synthesized on ribosomes attached to the ER (rough ER), and translocated through the membrane to the lumen by protein translocator, which is activated by start-transfer sequence; mature VEGF chain remains embedded to the membrane for further transport Polypeptide chain is synthesized on ribosomes attached to the ER (rough ER), and translocated through the membrane to the lumen by protein translocator,…
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR (cystic fibrosis transmembrane-conductance regulator) gene, which encodes the CFTR protein. The cells of the lining of the lungs contain high levels of the CFTR protein in their membranes. Normally, CFTR contains a chloride ion channel, which permits chloride ions to pass from inside the cells to the cells’ surfaces. The surface chloride ions are able to attract water in the lungs, allowing for the formation of a water layer on the cells’ surfaces. This thin water layer is necessary to allow the cilia, the tiny hairs on the surface of the lining cells to move back and forth easily. This motion permits the removal of mucus from the lungs. A particular error in the CFTR gene results in the replacement of the amino acid Phe with Ser at residue 508 of the CFTR protein. Individuals afflicted with CF most often experience the presence of thick, dry and sticky mucus in the lungs, leading to chronic infections and…
Bacteria In the petri dish in Figure 1, the bacteria Esherichia coli (E. coli) was grown and treated with disks soaked in different substances. Disk A was soaked in hand sanitizer, Disk B left untreated and Disk C was soaked in bleach The darker space around disks A and C where there is no growth of bacteria is called O Streptococcus pneumonae O ytic cycle O antibodies O the zone of inhibition 10 11 Nev
MACS are donut-shaped protein complexes of the complement system that create holes in bacterial cells to cause apoptosis. O 1) True O 2) False
can you explain why Bacillus anthracis can be pathogenic in a mouse and not be fought off by the immune system? I need help finding the answer in the article and explain in short answer link to article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC106848/
Why are mutations in the spike protein of special interest in regard to vaccine evasion? Because spike protein mutations are associated with increased virus transmission. O Because the spike protein is the target of COVID-19 vaccines. Because the gene for the spike protein mutates faster than the other genes. O Because mutations in the spike protein always are in the receptor-binding domain (RBD). Because spike protein mutations are associated with increased disease severity.
Severe combined immunodeficiency disease (SCID) is characterized by the complete lack ofan immune system. Strains of mice have been developed thathave SCID. When SCID mice that carry genetic predisposition toprion diseases are infected with PrPsc, they do not develop priondiseases. How do these facts relate to the transmission of priondiseases?
The annual flu shot is composed of either live attenuated influenza virus or influenza subunits (the envelope proteins neuraminidase and hemagglutinin). How does the annual flu shot protect you against infection?
The Gram-negative bacterium Yersinia pestis, thecausative agent of the plague, is extremely virulent. Uponinfection, Y. pestis injects a set of effector proteins intomacrophages that suppresses their phagocytic behaviorand also interferes with their innate immune responses.One of the effector proteins, YopJ, acetylates serines andthreonines on various MAP kinases, including the MAPkinase kinase kinase TAK1, which controls a key signalingstep in the innate immune response pathway. To deter-mine how YopJ interferes with TAK1, you transfect humancells with active YopJ (YopJWT) or inactive YopJ (YopJCA)and with FLAG-tagged active TAK1 (TAK1WT) or inactiveTAK1 (TAK1K63W), and assay for total TAK1 and for phos-phorylated TAK1, using antibodies against the FLAG tag oragainst phosphorylated TAK1 (Figure Q23–1). How doesYopJ block the TAK1 signaling pathway? How do you sup-pose the serine/threonine acetylase activity of YopJ mightinterfere with TAK1 activation?
The human genome contains more than 20 connexin-encoding genes. Several of these genes are expressed in high levels in the heart. Why are connexins so highly expressed in cardiac tissue?
The Minimum Inhibitory Concentration (MIC) is __________. - the concentration of antibiotic needed to prevent pathogenic bacteria growth - the concentration of antibiotic required to positively select for antibiotic resistance genes (ARG)

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