Back to Mr. Doe and his MRSA which over time is becoming more and more resistant to brincomycin. In the diagram below time is moving from left to right. Drag-drop the arrow-labels and the captions to describe how Mr. Doe's MRSA is evolving resistance to brincomycin. You only need to label one moment of diffusion, one pump and one molecule of brincomycin. Time 1 Time 2 Time 3 Efflux Pump brincomycin Diffusion into cell MRSA MRSA MRSA Efflux pump removes MRSA Efflux pump grabs brincomycin as fast as it diffuses in, cell MRSA antibiotic better, pumps it out faster, less brincomycin stays in cell MRSA Efflux pump grabs antibiotic inefficiently, pumps it out slowly, brincomycin stays in cell long enough to not damaged by the antibiotic What is happening: damage it MIC = 8 MIC MIC =1 MIC =2

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Defense Mechanism

Circumstances influence and compel people to behave in a certain way. One such behavior is a defense mechanism. It is employed by people to escape from unpleasant circumstances, thoughts and actions. Defense mechanisms are, thus, psychological strategies that help to avert and avoid unwanted feelings such as guilt or shame and situations such as threat and danger.