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If C3b was prevented to bind to C5 convertase, would the complement system still illicit an immune response? VWhat would be inhibited?

If C3b was prevented to bind to C5 convertase, would the complement system still illicit an immune response? VWhat would be inhibited?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Understanding the Complement System: Role of C3b and C5 Convertase **Question:** If C3b was prevented from binding to C5 convertase, would the complement system still elicit an immune response? What would be inhibited? **Detailed Explanation:** In the complement system, C3b plays a crucial role by binding to C5 convertase to initiate a sequence of immune responses. Preventing the binding of C3b to C5 convertase would disrupt a critical step in the complement pathway. - **C3b Function:** C3b is responsible for opsonization, marking pathogens for destruction. It also assembles with other components to form C5 convertase. - **C5 Convertase Role:** C5 convertase is essential for cleaving C5 into C5a and C5b. This cleavage leads to the formation of the membrane attack complex (MAC), which lyses pathogenic cells. **Inhibitory Consequence:** If C3b cannot bind to C5 convertase, the formation of the MAC is inhibited. This would impair the complement system's ability to directly lyse pathogens. The immediate immune response would be limited, affecting the overall defense mechanism against infections. **Educational Insight:** Understanding these interactions emphasizes the importance of each component in the complement system. Any disruption can have significant impacts on immune efficiency. This knowledge is fundamental for developing therapeutic interventions in immune-related disorders. **Graph and Diagram Explanation:** While the provided image does not include any graphs or diagrams, typically, a diagram of the complement pathway would illustrate the sequence of activation involving C3b, C5 convertase, and the formation of the MAC. Such diagrams are crucial for visualizing and comprehending the biochemical steps in immunology.
Transcribed Image Text:### Understanding the Complement System: Role of C3b and C5 Convertase **Question:** If C3b was prevented from binding to C5 convertase, would the complement system still elicit an immune response? What would be inhibited? **Detailed Explanation:** In the complement system, C3b plays a crucial role by binding to C5 convertase to initiate a sequence of immune responses. Preventing the binding of C3b to C5 convertase would disrupt a critical step in the complement pathway. - **C3b Function:** C3b is responsible for opsonization, marking pathogens for destruction. It also assembles with other components to form C5 convertase. - **C5 Convertase Role:** C5 convertase is essential for cleaving C5 into C5a and C5b. This cleavage leads to the formation of the membrane attack complex (MAC), which lyses pathogenic cells. **Inhibitory Consequence:** If C3b cannot bind to C5 convertase, the formation of the MAC is inhibited. This would impair the complement system's ability to directly lyse pathogens. The immediate immune response would be limited, affecting the overall defense mechanism against infections. **Educational Insight:** Understanding these interactions emphasizes the importance of each component in the complement system. Any disruption can have significant impacts on immune efficiency. This knowledge is fundamental for developing therapeutic interventions in immune-related disorders. **Graph and Diagram Explanation:** While the provided image does not include any graphs or diagrams, typically, a diagram of the complement pathway would illustrate the sequence of activation involving C3b, C5 convertase, and the formation of the MAC. Such diagrams are crucial for visualizing and comprehending the biochemical steps in immunology.
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