A few years ago researchers identified another protein involved in cell invasion by P. falciparum, Rh5.  PfRh5 is required in red blood cell invasion.  It binds to a specific protein (basigin) in red blood cell membranes and it shows almost no variation among P. falciparum strains.  What part(s) of this story is/are important relative to our discussion on malaria vaccines?  Option C: PfRh1 appears to be invariant All three of these observations (A-C) are crucial Option A: PfRh1 is required for cell invasion, i.e. no alternative pathways Option B: PfRh1 binds to basigin Options A and C

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