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7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What wo the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial ce migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated MRNA strand is isola and analysis shows a mutation located near the 3' end of the coding region. The 3'

7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What wo the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial ce migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated MRNA strand is isola and analysis shows a mutation located near the 3' end of the coding region. The 3'

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What would the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial cell migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated mRNA strand is isolated, and analysis shows a mutation located near the 3' end of the coding region. The 3' terminal coding sequence of the abnormal mRNA strand is shown below. 5-...-AUG-ACC-ACU-CCA-CUG-UUG-UUC-CAA-GGG-GAG-AGC-UAG-GUC-CGG- GGC-GGA-AAA-UUU-UAA-3 Using this sequence, can you explain a probable cause for the protein malfunction?
Transcribed Image Text:7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What would the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial cell migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated mRNA strand is isolated, and analysis shows a mutation located near the 3' end of the coding region. The 3' terminal coding sequence of the abnormal mRNA strand is shown below. 5-...-AUG-ACC-ACU-CCA-CUG-UUG-UUC-CAA-GGG-GAG-AGC-UAG-GUC-CGG- GGC-GGA-AAA-UUU-UAA-3 Using this sequence, can you explain a probable cause for the protein malfunction?
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