7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What wo the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial ce migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated MRNA strand is isola and analysis shows a mutation located near the 3' end of the coding region. The 3'
7. The following amino acid sequence represents part of a protein. The normal sequence and a mutant form are shown. By consulting Table 3-1 in your textbook, determine the double-stranded sequence of the corresponding section of the normal gene. Which strand is the strand that RNA polymerase "reads" and copies? What wo the sequence of the resulting mRNA be? What kind of mutation is the mutant protein most likely to represent? Normal -lys-arg-his-his-tyr-leu- Mutant 1 -lys-arg-his-his-cys-leu- Geneticists are studying a malfunctioning protein that causes impaired endothelial ce migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated MRNA strand is isola and analysis shows a mutation located near the 3' end of the coding region. The 3'
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...
Related questions
Topic Video
Question
![7. The following amino acid sequence represents part of a protein. The normal
sequence and a mutant form are shown. By consulting Table 3-1 in your textbook,
determine the double-stranded sequence of the corresponding section of the normal
gene. Which strand is the strand that RNA polymerase "reads" and copies? What would
the sequence of the resulting mRNA be? What kind of mutation is the mutant protein
most likely to represent?
Normal -lys-arg-his-his-tyr-leu-
Mutant 1 -lys-arg-his-his-cys-leu-
Geneticists are studying a malfunctioning protein that causes impaired endothelial cell
migration and angiogenesis. They have noticed that the amino acid sequence of the
protein is truncated compared to normal controls. The mutated mRNA strand is isolated,
and analysis shows a mutation located near the 3' end of the coding region. The 3'
terminal coding sequence of the abnormal mRNA strand is shown below.
5-...-AUG-ACC-ACU-CCA-CUG-UUG-UUC-CAA-GGG-GAG-AGC-UAG-GUC-CGG-
GGC-GGA-AAA-UUU-UAA-3
Using this sequence, can you explain a probable cause for the protein malfunction?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe6e2ef3b-4ced-4871-a279-ae69a95ed271%2F7fabe2cd-119c-4ee1-a900-d116c3bf54db%2F6xn16og_processed.jpeg&w=3840&q=75)
Transcribed Image Text:7. The following amino acid sequence represents part of a protein. The normal
sequence and a mutant form are shown. By consulting Table 3-1 in your textbook,
determine the double-stranded sequence of the corresponding section of the normal
gene. Which strand is the strand that RNA polymerase "reads" and copies? What would
the sequence of the resulting mRNA be? What kind of mutation is the mutant protein
most likely to represent?
Normal -lys-arg-his-his-tyr-leu-
Mutant 1 -lys-arg-his-his-cys-leu-
Geneticists are studying a malfunctioning protein that causes impaired endothelial cell
migration and angiogenesis. They have noticed that the amino acid sequence of the
protein is truncated compared to normal controls. The mutated mRNA strand is isolated,
and analysis shows a mutation located near the 3' end of the coding region. The 3'
terminal coding sequence of the abnormal mRNA strand is shown below.
5-...-AUG-ACC-ACU-CCA-CUG-UUG-UUC-CAA-GGG-GAG-AGC-UAG-GUC-CGG-
GGC-GGA-AAA-UUU-UAA-3
Using this sequence, can you explain a probable cause for the protein malfunction?
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
![Human Heredity: Principles and Issues (MindTap Co…](https://www.bartleby.com/isbn_cover_images/9781305251052/9781305251052_smallCoverImage.gif)
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning
![Biology: The Unity and Diversity of Life (MindTap…](https://www.bartleby.com/isbn_cover_images/9781337408332/9781337408332_smallCoverImage.gif)
Biology: The Unity and Diversity of Life (MindTap…
Biology
ISBN:
9781337408332
Author:
Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Human Heredity: Principles and Issues (MindTap Co…](https://www.bartleby.com/isbn_cover_images/9781305251052/9781305251052_smallCoverImage.gif)
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning
![Biology: The Unity and Diversity of Life (MindTap…](https://www.bartleby.com/isbn_cover_images/9781337408332/9781337408332_smallCoverImage.gif)
Biology: The Unity and Diversity of Life (MindTap…
Biology
ISBN:
9781337408332
Author:
Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Biology: The Dynamic Science (MindTap Course List)](https://www.bartleby.com/isbn_cover_images/9781305389892/9781305389892_smallCoverImage.gif)
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:
9781305389892
Author:
Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:
Cengage Learning
![Biology Today and Tomorrow without Physiology (Mi…](https://www.bartleby.com/isbn_cover_images/9781305117396/9781305117396_smallCoverImage.gif)
Biology Today and Tomorrow without Physiology (Mi…
Biology
ISBN:
9781305117396
Author:
Cecie Starr, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
![Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781938168130/9781938168130_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:
9781938168130
Author:
Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:
OpenStax College