7. The concentration of drug molecule in aqueous solution drops by 10% per month when stored at room temperature. If the degradation occurs by first order, what concentration will remain if a 5 mg/mL solution of the drug is stored under these conditions for 3 months? | A) 0.35 mg/mL B) 3.6 mg/mL C) 0.4 mg/mL D) 4.0 mg/mL
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- 6. The zero-order rate constant for a drug degradation is 0.05 mg/mL yr. If a 1g/100mL solution is prepared and stored, what is the shelf-life of the drug? A) 2 months B) 20 months C) 2 years D) 20 yearsWhat is the lipid-water partition coefficient of the drug below? Drug AMB Initial volume of water and concentration of drug in the water layer = Volume of octanol added to the water layer Concentration of the drug in the lipid layer 350 ml (25%) 150 ml 10% II ||||is the EC50 value--the drug concentration necessary for half of a maximal effect to occur--the same as the equilibrium dissociation constant Kd?
- Consider the following from the Ampicillin for Injection, USP package insert: For Intramuscular Use: Label Claim 250mg 500mg 1g 2g Amount of Diluent (mL) Approx. Volume (ml) 0.9 1.7 3.4 6.8 1 2 4 8 a) What is the amount of diluent needed to reconstitute a 1 g vial? b) What is the powder volume for a 1 g vial of ampicillin? Approx. Concentration (mg/mL) 250 250 250 250 Later in the package insert you see: For Direct Intravenous Use: Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mg vials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may also be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection or Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15 minutes. c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injection d) What is the total amount of volume that will…After oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %Estimate the new dose and dosing interval for morphine, a high extraction ratio drug in a patient with a Child-Pugh score of 8 if the drug is normally given at a dose of 30 mg every 8 hours. A) 7.5 mg every 8 hours B) 22.5 mg every 8 hours C) 30 mg every 6 hours D) 30 mg every 12 hours
- Identify the single most correct choice: () a) lodine can inactivate microbial cellular proteins. ( b) Alcohols may dissolve lipids and hence possess antimicrobial activities. c) Moist heat may result in protein denaturation and hence possess antimicrobial activities. 7 d) a and c e) b and c f) a, b and ce Mar 29 5) Order: Potassium Chloride 80 meq p.o. daily potassium Chloride 20 meq per 15 mL Supply: 150 mL Calculate the dosage in fl-oz 6) The order is for amoxicillin 500 mg PO. You have on hand a 150-mL bottle of dry powder. The directions read, "Add 105 mL of water and shake well i obtain 150 mL of suspension containing 250 mg per 5 mL." (a) How many milliliters will contain 500 mg? (b) Divided into 2 equal doses, how many milliliters will there be per dose?The Order is for o)alacin C 30omg 9sh lv. The drug is available in a vial containing aml Ê labeled 900mg doses of o)alacin will youget frum this vial ? How many
- Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-lifeWhat is the experimentally-determined minimum inhibitory concentration of the antibiotic being tested in this picture, based on the results shown in the picture? 0.06 0.125 0.25 1.0 μg/ml 8.0 µg/ml 0.5 µg/ml ○ 0.06 µg/ml µg/ml 0.5 1.0 2.0 4.0 8.0rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1