5. During prolonged fasting, amino acids derived from muscle proteins andconnective tissue become the main substrate for gluconcogenesis. How doesglutamate enter the gluconeogenesis? For answer:a) write a reaction of the glutamate conversion into a-ketoglutarate, name theenzyme, indicate the encrgy effect of the reaction;b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate andconsequent including of OAA to gluconcogenesis, specify the reactionsassociated with ATP consumption;c) name the hormones that accelerate gluconeogenesis during fasting andregulatory enzymes of the process; and describe the mechanism of signaltransduction by these hormones.

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Answered: 5. During prolonged fasting, amino…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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61. Degradation of glycogen in muscle fails to supply significant amounts of blood glucose because muscle lacks which of the following enzymes? A) Glucose-6-phosphatase B) Glucose-6-phosphate dehydrogenase C) Glycogen phosphorylase D) Phosphoglucomutase E) Phosphorylase kinase
Answer A,B,C
Gierke disease (glycogenosis) arises in the inherited defect of glucose-6-phosphatase and is accompanied by swelling of liver and hypoglycemia inpostabsorptive period. Why does a fasting blood glucose level of patients fallsharply in the morning? To answer this question:a) draw the scheme of the mobilization of the main reserve homopolysaccharideinvolving glucose-6-phosphatase in a healthy person and indicate the localizationof this process in the organism;b) explain the role of this metabolic pathway.
In own words, give 5 or more reasons why most of the clinical features of the diseases a-ketoglutarate dehydrogenase deficiency, succinate dehydrogenase deficiency, and fumarase deficiency involve muscle and nerve tissue? and explain those reasons.
The diabetic body's reliance on ketogenesis to provide energy due to the unavailability of glucose causes serious health and toxicity concerns in these individuals. 1) Describe the role of ketogenesis in diabetes, why the body elects this metabolic pathway, and its resultant benefits and consequences. 2) Describe the role of ketogenesis in a ketogenic diet, why this can be considered a desired metabolic state for individuals, and the benefits and consequences of ketogenesis in these intentional circumstances. Rationalize the differences between these two ketogenic instances.
. Name the three unique reactions in gluconeogenesis.
E3 of the pyruvate dehydrogenase complex performs which main function? A) removing a proton from TPP forming a carbanion b) catalyzing the condensation of the TPP carbanion with pyruvate to form hydroxyethyl-TPP c) oxidation and transfer of the hydroxyethyl group to lipoic acid d) reoxidation of lipoic acid in order to keep the reaction going Once acetyl-CoA is formed, it usually takes one of two paths. The first is further oxidation in the citric acid cycle. The second is: a) conversion to oxaloacetate which generates glucose by gluconeogenesis b) synthesis of galactose c) activates transcription factors which signal the synthesis of peptidase enzymes d) it is used in the synthesis of fatty acids.
Select which of the following enzymes unique to glycolysis are also sites of regulation for glycolysis. Select all that apply. a) glyceraldehyde 3 P dehydrogenase b) PFK c) pyruvate kinase d) hexokinase e) enolase f) phosphoglycerate mutase
In the Cori cycle, the lactate product of glycolysis in muscle is transformedback into glucose by the liver. (a) List the enzymes involved in the lactate → glucose pathway. (b) What is the net gain/loss of ATP for one round of the Cori cycle (glucose → lactate → glucose)?
Back in the 1930s, a chemical called DNP (2,4-Dinitrophenol) was prescribed as a weight loss pill. Describe how DNP is a metabolic poison , and why it was thought to be a good mechanism for weight loss?
1) An average middle-aged person weighing 90 kg (200 lb.) contains 15 % body fat stored in adipose tissue. a) Calculate the amount of energy stored as fat in this person in kilojoules, assuming that energy yield from fat is 37 kJ/g. b) If this same amount of energy were stored in hydrated glycogen rather than fat (hydrated glycogen has an energy yield of 6 kJ/g), how much would the person weight in kilograms and in pounds?
If α-ketoglutarate is removed from TCA cycle and used to make glutamate, how many of each of the cofactors (not intermediates) and high energy molecules in the TCA cycle are lost? How much ATP does this equate to (NADH = 2.5 ATP, FADH2 = 1.5 ATP)?

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