40. Propose that all three carbon atoms in glycerol is labeled with 14C. The labeled glycerol is allowed toundergo metabolism in the genetically modified liver cell, in which the triose phosphate isomerase is nolonger functioning. Which of the following are most likely to be true?A. All three carbon atoms in pyruvate can be labeled with radioisotope in the genetically modifiedliver cellB. All six carbon atoms in glucose can be labeled with radioisotope in the genetically modified livercellC. Both A and BD. Neither A nor B

Glycerol is a molecule commonly found in biological systems and serves as a precursor for various…

Answered: 40. Propose that all three carbon atoms…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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37.Assume that the phosphoryl group in the shown chemical (Phosphoenolpyruvate (PEP)) is labeled with 32P radioisotope. The radioisotope labeled chemical is then allowed to undergo gluconeogenesis in liver cells. Which of the phosphoryl groups in fructose-1,6-bisphosphate are labeled with radioisotope? (Assume that the only fate of the radioisotope chemical is to undergo gluconeogenesis in the liver)a. The phosphoryl group that is attached to the C-1 of fructoseb. The phosphoryl group that is attached to the C-6 of fructosec. Bothd. Neither a nor b
A child with coarse facies, corneal clouding, joint stiffness and mental retardation is found to have a Damage to this enzyme directly affects which of partial defect in N-acetylglucosaminotransferase. the following biochemical functions? A. Formation of polysomes B. Microtubule attachment to centrioles C. Synthesis of ribosomal RNA D. Targeting of enzymes for lysosomes E. Transport of sugars into mitochondria
11.Discuss three mechanisms through which lactate can be used as an energy source.
4 8. Rotenone is a chemical that naturally occurs in plants. It is a broad-spectrum poison, meaning it is toxic to many types of organisms, including fish, insects, and other pests. Rotenone inhibits the transfer of electrons from one electron transport chain complex to another (complex I to ubiquinone). a. Would you expect rotenone poisoning to affect the following molecules (yes or no)? If so, would you expect them in increase or decrease? Molecule Acetyl-CoA ATP NADH Will levels change? (Yes or no) Yes No yes If yes, will the levels increase or decrease?
Propose that all three carbon atoms in glycerol is labeled with 14C. The labeled glycerol is allowed to undergo metabolism in the genetically modified liver cell, in which the triose phosphate isomerase is no longer functioning. Which of the following are most likely to be true?a. All three carbon atoms in pyruvate are radioisotope labeled in the genetically modified liver cellb. All six carbon atoms in glucose are radioisotope labeled in the genetically modified liver cellc. Bothd. Neither
Which of the statements below regarding glyphosate are true? (Choose all true statements) A.Glyphosate interacts with EPSP synthase because it resembles the substrate S-3P B.The interaction of S-3P is necessary for glyphosate binding. C.Glyphosate likely binds to both conformations of EPSP synthase shown in question 7. D.Glyphosate decreases Km for S-3P and thus likely the increases the affinity of the enzyme for substrate E.Glyphosate likely increases feedback inhibition by the product of the reaction EPSP
38. The shown reaction is one of the four repeating steps during fatty acid biosynthesis. Which of the following statements is correct? 유 CH3-C-CH₂-C-S-ACP A B OH 유 CH3-C-CH₂-C-5-ACP → A. The small molecule in box A is NADPH + H* B. It is the second reduction reaction during fatty acid biosynthesis C. Both A and B D. Neither A nor B
4) Phosphofructokinase (PFK) is a highly regulated enzyme in glycolysis. ADP (and also AMP - adenosine monophosphate) bind to allosteric sites on PFK's structure, causing additional active sites (fructose-6-phosphate binding sites) to open. Conversely, ATP and PEP (phosphoenolpyruvate) bind to different allosteric sites, resulting in PFK's active sites closing. a) How does an allosteric activator work? What is the allosteric activator? When would it be important for PFK to be activated? Function: Allosteric Activator(s): Importance: b) How does an allosteric inhibitor work? What is the allosteric inhibitor? When would it be important for PFK to be inhibited? Function: Allosteric Inhibitor(s): Importance: c) How does this relate to the ideas of homeostasis and why does it make sense to control this system homeostatically? Use a specific example to make your comparison.
4) Suppose some yeast cells undergoing gluconeogenesis were treated with a 1:1 mixture of the two labeled pyruvate molecules shown below (one pyruvate is labeled with ¹4C at C1 and ¹³C at C3; the other pyruvate is labeled with ¹4C at C3 and ¹3C at C2. Assume that the labeled pyruvate molecules are the only source of carbon to make glucose via gluconeogenesis. Draw the resulting mixture of glucose molecules and clearly show the location of ¹4C and/or ¹³℃ in each glucose. 13CH3 14CH3 13C

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