4) Phosphofructokinase (PFK) is a highly regulated enzyme in glycolysis. ADP (and also AMP - adenosine monophosphate) bind to allosteric sites on PFK's structure, causing additional active sites (fructose-6-phosphate binding sites) to open. Conversely, ATP and PEP (phosphoenolpyruvate) bind to different allosteric sites, resulting in PFK's active sites closing. a) How does an allosteric activator work? What is the allosteric activator? When would it be important for PFK to be activated? Function: Allosteric Activator(s):. Importance: b) How does an allosteric inhibitor work? What is the allosteric inhibitor? When would it be important for PFK to be inhibited? Function: Allosteric Inhibitor(s):. Importance: c) How does this relate to the ideas of homeostasis and why does it make sense to control this system homeostatically? Use a specific example to make your comparison.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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4) Phosphofructokinase
(PFK) is a highly regulated enzyme in
glycolysis. ADP (and also AMP - adenosine monophosphate) bind to
allosteric sites on PFK's structure, causing additional active sites
(fructose-6-phosphate binding sites) to open. Conversely, ATP and
PEP (phosphoenolpyruvate) bind to different allosteric sites,
resulting in PFK's active sites closing.
a) How does an allosteric activator work? What is the allosteric
activator? When would it be important for PFK to be activated?
Function:
Allosteric Activator(s):
Importance:
b) How does an allosteric inhibitor work? What is the allosteric inhibitor? When would it be
important for PFK to be inhibited?
Function:
Allosteric Inhibitor(s):
Importance:
c) How does this relate to the ideas of homeostasis and why does it make sense to control this
system homeostatically? Use a specific example to make your comparison.
Transcribed Image Text:4) Phosphofructokinase (PFK) is a highly regulated enzyme in glycolysis. ADP (and also AMP - adenosine monophosphate) bind to allosteric sites on PFK's structure, causing additional active sites (fructose-6-phosphate binding sites) to open. Conversely, ATP and PEP (phosphoenolpyruvate) bind to different allosteric sites, resulting in PFK's active sites closing. a) How does an allosteric activator work? What is the allosteric activator? When would it be important for PFK to be activated? Function: Allosteric Activator(s): Importance: b) How does an allosteric inhibitor work? What is the allosteric inhibitor? When would it be important for PFK to be inhibited? Function: Allosteric Inhibitor(s): Importance: c) How does this relate to the ideas of homeostasis and why does it make sense to control this system homeostatically? Use a specific example to make your comparison.
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