3.) Tumors & Lactate. When tumor cells spread to regions of the body with low oxygen levels, the tumor cells generate adenosine triphosphate (ATP) from breaking down glucose into lactate. This is called the Warburg theory of cancer. How do DNA mutations that are present in these tumor cells enable them to thrive in low and high oxygen microenvironments? Write down your hypothesis.
3.) Tumors & Lactate. When tumor cells spread to regions of the body with low oxygen levels, the tumor cells generate adenosine triphosphate (ATP) from breaking down glucose into lactate. This is called the Warburg theory of cancer. How do DNA mutations that are present in these tumor cells enable them to thrive in low and high oxygen microenvironments? Write down your hypothesis.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:3.) Tumors & Lactate. When tumor cells spread to regions of
the body with low oxygen levels, the tumor cells generate
adenosine triphosphate (ATP) from breaking down glucose into
lactate. This is called the Warburg theory of cancer. How do
DNA mutations that are present in these tumor cells enable
them to thrive in low and high oxygen microenvironments?
Write down your hypothesis.
Glucose
CYTOSOL
Glycolysis
Pyruvate
No O, present
Fermentation
O, present
Aerobic cellular
respiration
MITOCHONDRION
Ethanol,
lactate, or
other products
Acetyl CoA
CITRIC
ACID
CYCLE
A Figure 9.18 Pyruvate as a key juncture in catabolism. Glycol-
ysis is common to fermentation and cellular respiration. The end prod-
uct of glycolysis pyruvate, represents a fork in the catabolic pathways
of glucose oxidation. In a facultative anaerobe or a muscle cell, which
are capable of both aerobic cellular respiration and fermentation, pyru-
vate is committed to one of those two pathways, usually depending on
whether or not aygen is present
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