3. Draw an IgG antibody. Label the following:a. The heavy and light chainsb. The constant and variable domainsc. The Fab and Fc domainsd. The antigen binding site,e. The hinge regionf. The amino and carboxyl terminig. Indicate approximately the location of critical glycosylation sitesh. Indicate approximately where the CDR (hypervariable domains) are located

Answered: Image /qna-images/answer/ff832266-4b88-4f2c-8503-6793e6dc4bec.jpg

Answered: 3. Draw an IgG antibody. Label the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Which of the following is not used as a treatment for autoimmune diseases? Select one: A. Anti-IL2 receptor B. Anti-CD4 C. Anti-MHC D. Anti-CCR5 E. Anti-T cell receptor
1. Name and briefly describe the function of three different classes of proteins that participate in recognition events to regulate immune responses. 2. Toll receptors bind ligands through diverse mechanisms. Briefly describe the three binding mechanisms discussed in class for TLR1/2, TLR3 and TLR4.
Amino acid variation among MHC class II allotypes that present antigens to CD4 T cells is concentrated a. where MHC contacts the co-receptors CD4 or CD8 b. in the β chain, because the α chain is monomorphic c. where the MHC molecule contacts peptide and the T-cell receptor d. in the α chain, because the β chain is monomorphic e. throughout both the α and β chains in all domains.
1. True or False: Negative selection of transitional B cells in the spleen removes B cell clones whose BCR recognizes self antigens that weren't expressed in the bone marrow. 2. Which of the following statements about the pre-BCR is false? A. Transiently expressed with the IgM isotype in its constant region. B. Signals in an antigen-independent manner. C. Consists of a rearranged immunoglobulin light chain paired with a surrogate immunoglobulin heavy chain (VpreB). D. Consists of a rearranged immunoglobulin heavy chain paired with a surrogate light chain (VpreB + lambda5) 3. True or False: The class switch recombination of IgA antibodies is induced by TGF-beta or IL-21, and IgA antibodies can be transported across the placental interface as pentameric (5 member) oligomers. 4. A newborn infant has not started breastfeeding yet. Which isotype of maternal antibody/antibodies does the newborn have that they received from their mother while in utero? A. IgD only B. IgA only…
Complexes of IgG bound to soluble multivalent antigens can activate the classical pathway on the complex, targeting it for of complement, resulting in the deposition of endocytic uptake by cells bearing. Select one: a. C4b; CR2 and Fc receptors b. c. C5-9; CR1 and Fc receptors d. C3b; CR1 and Fc receptors e. C2a; CR2 and Toll-like receptors C3b; CR2 and Toll-like receptors
How may B cells be activated? Select all that apply. Select one or more: a. Crosslinking of BCRS and binding of B-cell co-receptor to C3d. b. Recognition of MHC II and epitope on B-cell with TCR of TFH cell. c. Binding of CR2 to iC3b. d. Binding of B-cell to antigen displayed on FDC.
a. What are the number of total chromosomes that carries the genes encoding heavy and light chain polypeptides in a single B cell (in human)? b. From the total number of chromosomes carrying genes for immunoglobulin peptides from question a, how many encode the heavy and light chains actually expressed by a single B cell?
In organ transplantation, minor histocompatibility antigens Select one: A. can trigger hyperacute graft rejection. B. are ABO blood group antigens. C. can be detected by cross matching. D. are MHC-bound peptides that differ between donors and recipients as a result of genetic polymorphisms. E. should be identical between donors and recipients.
1. Review the following link (don't get caught up in details) to determine if our immune cells use paracrine signaling during immune response? https://www.niaid.nih.gov/research/immune-cells 2. Determine if histamine which is released during allergy is an example of paracrine signaling or not? https://www.hoffmancentre.com/mast-cell-activation-syndrome-histamine- immune-system-runs-rampant/
(1) In antibody structure, where are can we find unique variable domains? A. at the tip of each polypeptide chain B. on the stem region of the antibody C. at the bottom of each polypeptide chain D. only on immunoglobulin E (2) The stem region of the antibody determines the: A. general immunological mechanism of action B. specific inflammatory response C. specific immunological mechnism of action D. shape of the variable domains (3) Antibodies are proteins that consists of ------ polypeptides in a ------ shaped structure. A. three, X B. four, Y C. five, clover D. two, Y
The autoimmune attack on nAChR leads to a decrease in the number of available receptors due to antibodies binding to the receptors. 2. Where could you find these antibodies binding? Choose ALL that apply. a. effectors of the parasympathetic nervous system b. effectors of the somatic nervous system c. effectors of the sympathetic nervous system d. pre-ganglionic neurons of the parasympathetic nervous system e. pre-ganglionic neurons of the sympathetic nervous system f. post-ganglionic neurons of the parasympathetic nervous system g. post-ganglionic neurons of the sympathetic nervous system PLEASE EXPLAIN YOUR REASONING!
Fig. 1. AKAP11 and RIα are degraded by autophagy. (A) Brain lysates of Atg7F/F (Control) and Atg7F/F-SynCre (cKO) were subjected to immunoblottinganalysis with the indicated antibodies. (B) Quantification of protein levels in A. Unpaired Student’s t tests were used, and values are presented as mean ± SEM(n = 3 mice/genotype). **P < 0.01; ***P < 0.001; ns, not significant. (C) Brain lysates of Atg14F/F (Control) and Atg14F/F-SynCre (cKO) were subjected toimmunoblotting analysis with the indicated antibodies. (D) Quantification of protein levels in C. Unpaired Student’s t tests were used, and values are presented as mean ± SEM (n = 4 mice/genotype). **P < 0.01; ***P < 0.001; ns, not significant. (E) Atg7 WT and Atg7 KO MEF cells were nutrient starved by usingEBSS for the indicated times, and cells were assayed by immunoblotting analysis with the indicated antibodies. (F) Quantification of the protein levels from Ewas obtained by normalizing the level of proteins to Actin,…

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