2.Explain what you understand by the term selectivity with respect to molecules binding tothe active site of a receptor.

Signal transduction is a process in which signals from the extracellular level enter the…

Answered: 2. Explain what you understand by the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Non-specific interactions present a real challenge to co-IP experiments because non-physiological binding to the target complex is likely to occur. Group of answer choices True False
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P CO HI F. sum21.ex1.137 Accessibility Mo 日- Which of the following molecules generally possesses a complex shape that allows the molecule to function as tools and machinery that essentially do all the work within a living cell? 15. A. triglycerides B. proteins C. carbohydrate D. A and Bare correct. 16. Which of the following molecules is NOT involved in cell-to-cell signaling? A nroctaalandine Give %00% kidomi 56°F 近 Insert F8 F6 & %24 8. K 2 G oW N M
2.2. Draw a schematic pathway, specifically naming components and state (in a few sentences) how membrane bound Phosphatidylinsoitol (PI) leads to the regulation of protein function by the phosphorylation.
Plant junctions Choose. ion Bacteriophages can recognize the host cell by: O a. Glycoprotein that recognizes a specific protein on a bacterial cell O b. Binding of a viral protein to a receptor on the bacteria cell using the lock and key fit put of O c. Glycoproteins that help the virus to bind to a receptor protein on a bacterial cell O d. Binding of the viral receptor to a protein on a bacteria cell using the lock and key fit un e. Viral envelop that fuses with the plasma membrane of a bacterial cell estion Estrogen is a female hormone that helps develop and maintain the reproductive system. Estrogen is produced in Type here to search
9. Shown below is a binding pocket for a protein with a ligand bound. The ligand interacts with a serine and a valine side chain. ligand a. Briefly explain, in terms of Ka, the effect of a mutation that replaces the serine residue with a valine residue. b. Briefly explain, in terms of Kd, the effect of a mutation that alters the ligand (as seen below) binding to the original, unmutated, binding site. :0: ligand 2
Small molecules are used as inhibitors of protein action - as drugs. They most often do this by blocking the active site within the protein. Potential drugs can be screened computationally to determine if they are strongly bound to the protein. Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2- carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein (abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP. (a) Explain what types of interactions, both intermolecular and intramolecular, that a molecular mechanics forcefield must be able to describe in order to be able to accurately determine the geometry of BCMAP in the protein. Identify which interactions will be the most important to describe accurately. Figure 1.4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue, red, and…
3. Enzyme specificity. To determine the specificity of substrate binding for a particular enzyme/protein, structurally related compounds may be used as potential substrates and Km values may be calculated. However, many compounds structurally related to the substrate may bind to the active site but cannot be converted to product. In these instances, the substrate analogs are used as potential competitive inhibitors of substrate binding. Low K, values indicate high affinity of the enzyme for the inhibitor, whereas high K,values indicate low binding affinity. Consider the enzyme xanthine oxidase, which catalyzes the formation of uric acid from the purine bases hypoxanthine or xanthine in humans. The Km for hypoxanthine is 15.0 μM and for xanthine it is 45.0 μM. A few compounds used as competitive inhibitors of the normal substrate hypoxanthine are listed in the table below with their K; values. Comparing the structures of hypoxanthine with the listed substrate analogs, what can you…
1. The CFTR protein is a chloride channel in the cell membrane. Use your understanding of the biochemical properties/categories of amino acids and how they interact with membrane phospholipids to predict the distribution of charged/polar, and non-polar amino acids within the domains of CFTR listed below. Consider one category to include the charged amino acids and the polar amino acids and the other category to include the non-polar amino acids. For each domain, predict which category of amino acids is likely to be most abundant. Also, explain the rationale behind your prediction. Protein domain Prediction (Charged/Polar or Non-Polar amino acids?) Explanation for prediction TMD1 and TMD2 (transmembrane domains, parts 1-12) ECLs and ICLs (extracellular and intracellular loops) NBD1 and NBD2 R
1F. Please help me in detail. for molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Draw a reaction scheme that includes both the substrate and the inhibitor under study here. Be sure to label KI, Ks, kp

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2. Explain what you understand by the term selectivity with respect to molecules binding to the active site of a receptor.