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structure so they can which below, II. While there are many different types of inhibitors, most have a very similar Of the molecules compete with the normal substrate (in this case dopamine). compound do you think has the most promise as an inhibitor?

structure so they can which below, II. While there are many different types of inhibitors, most have a very similar Of the molecules compete with the normal substrate (in this case dopamine). compound do you think has the most promise as an inhibitor?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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**Educational Content: Analyzing Inhibitor Structures** **Question II:** While there are many different types of inhibitors, most have a very similar structure, so they can compete with the normal substrate for the active site. From these possible inhibitor compounds, which do you think has the most promise as an inhibitor? **Compounds:** 1. **Carbidopa:** - Structure: Contains a benzene ring with a hydroxyl group (OH) attached, an amine group (NH), and an additional hydroxyl group with a carboxyl side chain. 2. **Alendronate:** - Structure: Features a central nitrogen connected to a phosphonate group (PO₃H₂) and adjacent hydroxy groups. 3. **Raloxifene:** - Structure: Has a complex aromatic backbone comprising multiple fused rings. **Using the same amino acid orientation as you arrived at for Part I, show which inhibitor is most promising:** **Diagram Explanation:** A circular diagram is present with segments labeled as follows: - a.a.#1 - a.a.#2 - a.a.#3 - a.a.#4 - a.a.#5 - a.a.#6 Each segment likely corresponds to specific amino acids involved in the orientation under study for determining inhibitor binding and effectiveness.
Transcribed Image Text:**Educational Content: Analyzing Inhibitor Structures** **Question II:** While there are many different types of inhibitors, most have a very similar structure, so they can compete with the normal substrate for the active site. From these possible inhibitor compounds, which do you think has the most promise as an inhibitor? **Compounds:** 1. **Carbidopa:** - Structure: Contains a benzene ring with a hydroxyl group (OH) attached, an amine group (NH), and an additional hydroxyl group with a carboxyl side chain. 2. **Alendronate:** - Structure: Features a central nitrogen connected to a phosphonate group (PO₃H₂) and adjacent hydroxy groups. 3. **Raloxifene:** - Structure: Has a complex aromatic backbone comprising multiple fused rings. **Using the same amino acid orientation as you arrived at for Part I, show which inhibitor is most promising:** **Diagram Explanation:** A circular diagram is present with segments labeled as follows: - a.a.#1 - a.a.#2 - a.a.#3 - a.a.#4 - a.a.#5 - a.a.#6 Each segment likely corresponds to specific amino acids involved in the orientation under study for determining inhibitor binding and effectiveness.
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