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2. Consider a hypothetical organism that produces 12 moles of NADH and 2 moles of FADH2 during the oxidation of glucose. If 4 of the 12 moles of NADH were synthesized during glycolysis, determine the expected ATP output from these coenzymes if the G-3-P shuttle system is used. 36 ATP 32 ATP 34 ATP 42 ATP

2. Consider a hypothetical organism that produces 12 moles of NADH and 2 moles of FADH2 during the oxidation of glucose. If 4 of the 12 moles of NADH were synthesized during glycolysis, determine the expected ATP output from these coenzymes if the G-3-P shuttle system is used. 36 ATP 32 ATP 34 ATP 42 ATP

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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**Question 2** Consider a hypothetical organism that produces 12 moles of NADH and 2 moles of FADH2 during the oxidation of glucose. If 4 of the 12 moles of NADH were synthesized during glycolysis, determine the expected ATP output from these coenzymes if the G-3-P shuttle system is used. **Options:** - □ 36 ATP - □ 32 ATP - □ 34 ATP - □ 42 ATP Explanation: To determine the expected ATP output, consider the following conversion factors: - NADH from glycolysis, when utilizing the G-3-P shuttle system, typically yields 1.5 ATP per mole. - NADH from the mitochondrial matrix yields 2.5 ATP per mole. - FADH2 yields 1.5 ATP per mole. Calculate the ATP yield for: - NADH produced during glycolysis: 4 moles x 1.5 ATP - NADH produced in the mitochondria: (12 - 4) moles x 2.5 ATP - FADH2: 2 moles x 1.5 ATP Sum these values for the total ATP output.
Transcribed Image Text:**Question 2** Consider a hypothetical organism that produces 12 moles of NADH and 2 moles of FADH2 during the oxidation of glucose. If 4 of the 12 moles of NADH were synthesized during glycolysis, determine the expected ATP output from these coenzymes if the G-3-P shuttle system is used. **Options:** - □ 36 ATP - □ 32 ATP - □ 34 ATP - □ 42 ATP Explanation: To determine the expected ATP output, consider the following conversion factors: - NADH from glycolysis, when utilizing the G-3-P shuttle system, typically yields 1.5 ATP per mole. - NADH from the mitochondrial matrix yields 2.5 ATP per mole. - FADH2 yields 1.5 ATP per mole. Calculate the ATP yield for: - NADH produced during glycolysis: 4 moles x 1.5 ATP - NADH produced in the mitochondria: (12 - 4) moles x 2.5 ATP - FADH2: 2 moles x 1.5 ATP Sum these values for the total ATP output.
Expert Solution
Step 1: Relevance of glycerol 3 phosphate shuttle

NAD2H generated by glycolysis is unable to enter inside mitochondria for electron transport chain as mitochondrial membrane is impermeable to it. Hence glycerol 3 phosphate shuttle is used which would regenerate electrons from NADH inside the mitochondria. 

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