In normal mitochondria, which of the following is true for the rate of NADHconsumption (oxidation)?Select all that applyBe very low if the ATP synthase is inhibited, but increase when an uncoupler(equalizer of H+ concentration) is addeddecrease if mitochondrial ADP is depletedIncrease in active muscle and decrease in inactive muscledecrease when cyanide is added to prevent electron transfer through theelectron transport chain

Mitochondria occupy a significant part of the cytoplasmic extent of eukaryotic cells, and that they…

Answered: In normal mitochondria, which of the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Assume that a person was born with a defective NADH dehydrogenase complex, the complex that allows electron transport chain (ETC) to make ATP from NADH. Following consumption of a diet rich in carbohydrates and fats, would you expect this person to be able to produce any ATP by oxidative phosphorylation? Explain your answer?
Oxidative phosphorylation generates ATP using the reducing power of [NADH, FADH2 or malate] to move electrons down a series of carriers to ultimately produce a [phosphate gradient or protons gradient] across the inner mitochondrial membrane, which is used by ATP synthase to make ATP. ATP synthase harnesses the energy stored in both [charge and concentration gradients or electostatic and van der waals interations] to achieve high energy phosphate bond synthesis. If the ion gradient across the inner membrane is dissipated by the expression of UCP1, ATP is not synthesized and [heat is generated or electron transport is blocked]. The final electron acceptor in the electron transport chain is [oxygen or carbon dioxide] with water as a product.
Dinitrophenol (DNP) is a lipid soluble H+ binding drug that equalizes the H+ concentration across the inner mitochondrial membrane. Which of the following would you predict to occur upon addition of DNP to a cell? Halt in both pyruvate oxidation and ATP synthesis Halt in pyruvate oxidation and continuation in ATP synthesis Continuation in pyruvate oxidation and halt in ATP synthesis Continuation in both pyruvate oxidation and ATP synthesis
The image shows the flow of electrons through electron carriers I, II, III, and IV within the mitochondrial inner membrane. The electronegativity of the protein carriers determines their capacity to attract electrons. Based on the image, which of the following best describes the electronegativity of the carriers and the synthesis and utilization of ATP during the electron-transfer process? Electron carrier I is the least electronegative, and electron carrier IV is the most electronegative. ATP is required for electron transfer between carriers. Electron carrier I is the most electronegative, and electron carrier IV is the least electronegative. ATP is not required for electron transfer between carriers. Electron carrier I is the most electronegative, and electron carrier IV is the least electronegative. ATP is utilized in a distinct reaction, not directly coupled with electron transfer. Electron carrier I is the least electronegative, and electron carrier IV is the most…
In phase II of ETS diagram and label the ATP synthase along with the inner mitochondrial membrane it is sitting in. Your diagram must show the intermembrane space and the mitochondrial matrix. Describe how it works step by step
Calculate the total amount of ATP’s that can be produced by the Krebs cycle and the resultant oxidative phosphorylation, if 3 glucose molecules are metabolized. Do not include glycolysis and acetyl CoA conversion
Describe the movement of protons that is caused by the action of the mitochondrial electron transport chain and explain why more ATP can be generated from the addition of NADH to the system as opposed to succinate.
What is the difference in ATP yield per glucose molecule between the malate-aspartate shuttle and the glycerophosphate shuttle? Hint: Consider electron carriers produced in glycolysis per glucose, the number of protons pumped as a result of the electron entry to the ETC, and the number of cytosolic ATP produced. Enter numeric value only.
Although the outer mitochondrial membrane is permeable to all small molecules, the inner mitochondrial membrane is essentially impermeable in the absence of specific transport proteins. Consider this information answer: Present two types of benefits derived from separating the reactions of glycolysis in the cytosol from those that occur during the citric acid cycle in the mitochondrion.
During cellular respiration, for each single glucose molecule 10 NADH molecules and 2 FADH2 molecules are produced. However, when tabulating how much ATP is synthesized, we consider the ATP yield from 8 NADH molecules and 4 FADH2 molecules. Explain why.
The maximal recovery of energy from oxidation of glucose to CO2 and H2O requires the coordination of the glycolysis, tricarboxylic acid cycle, the electron transport chain and the ATP synthase. During these processes each molecule of glucose generates: 6 molecules of NADH and 1 molecules of FADH2. 10 molecules of NAD* and2 molecules of FADH2. 10 molecules of NADH and 2 molecules of FAD. 10 molecules of NADH and 2 molecules of FADH2. 10 molecules of NAD* and 1 molecules of FADH2.
Briefly explain the structure and sequence of the Mitochondrial Electron Transport Chain while including each Complex, journeys electrons take through the chain and how this produces gradients for ATP synthesis. Include in the short answer how uncoupling can be used to produce heat and give two real-world examples.

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