Answered: 1.Would you expect a solution of high…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

1.Would you expect a solution of high salt to be able to denature ribonuclease? Why or why not? 2. You have read in the Human Perspective that (1) mutations in the PRNP gene can make a polypeptide more likely to fold into the PrPSc conformation, thus causing CJD and (2) exposure to the PrPSc prion can lead to an infection that also causes CJD. How can you explain the occurrence of rare sporadic cases of the disease in persons who have no genetic propensity for it? 3. Persons who are born with Down syndrome have an extra (third) copy of chromosome #21 in their cells. Chromosome #21 contains the gene that encodes the APP protein. Why do you suppose that individuals with Down syndrome typically develop Alzheimer’s disease at an early age?

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