Answered: 1. We saw how evolution has led to the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

1. We saw how evolution has led to the existence of protein families composed of related molecules with similar functions. A few examples are also known where proteins with very similar functions have primary and tertiary structures that show no evidence of evolutionary relationship. Subtilisin and trypsin, for example, are two protein-digesting enzymes (proteases) that show no evidence they are homologous despite the fact that they utilize the same mechanism for attacking their substrates. How can this coincidence be explained? 2. Would you agree with the statement that many different amino acid sequences can fold into the same basic tertiary structure? What data can you cite as evidence for your position. 3. In the words of one scientist: “The first question any structural biologist asks upon being told that a new [protein] structure has been solved is no longer ‘What does it look like?; it is now What does it look like?’” What do you suppose he meant by this statement?

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