Levels of protein structure (a) Primary structure Amino end H H R. H R4 H Re Carboxyl end H|| C C N. IH | H -- R, H R5 (b) Secondary structure R H H- R. H.... 0=C N-H. N-H.. ... H .• OC H N-H. R H C-R N-H -H H R Hydrogen bonds between amino acids at different locations in polypeptide chain H R HR a helix Pleated sheet (c) Tertiary structure (d) Quaternary structure Heme. Heme group B polypeptide FIGURE 9-3 A protein can have four levels of structure. (a) Primary structure. The sequence of amino acids defined by their R groups. (b) Secondary structure. The polypeptide can form a helical structure (an az helix) or a zigzag structure (a B-pleated sheet). The B-pleated sheet has two polypeptide segments arranged in opposite polarity, as indicated by the arrows. (c) Tertiary structure. The heme group is a nonprotein ring structure with an iron atom at its center. (d) Quatemary structure illustrated by hemoglobin, which is composed of four polypeptide subunits: two a subunits and two B subunits.

Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The primary protein structure is shown in Figure 9-3(a).
Where in the mRNA (near the 5′
or 3′
end) would a mutation in R2 be encoded?

Levels of protein structure
(a) Primary structure
Amino end
H
H
R.
H
R4
H
Re
Carboxyl end
H||
C
C
N.
IH |
H
--
R,
H
R5
(b) Secondary structure
R
H
H-
R.
H.... 0=C
N-H.
N-H.. ...
H
.• OC
H
N-H.
R
H
C-R
N-H
-H
H R
Hydrogen bonds between amino acids
at different locations in polypeptide chain
H R
HR
a helix
Pleated sheet
(c) Tertiary structure
(d) Quaternary structure
Heme.
Heme group
B polypeptide
FIGURE 9-3 A protein can have four levels of structure. (a) Primary structure. The sequence of amino acids
defined by their R groups. (b) Secondary structure. The polypeptide can form a helical structure (an az helix) or a
zigzag structure (a B-pleated sheet). The B-pleated sheet has two polypeptide segments arranged in opposite
polarity, as indicated by the arrows. (c) Tertiary structure. The heme group is a nonprotein ring structure with an
iron atom at its center. (d) Quatemary structure illustrated by hemoglobin, which is composed of four polypeptide
subunits: two a subunits and two B subunits.
Transcribed Image Text:Levels of protein structure (a) Primary structure Amino end H H R. H R4 H Re Carboxyl end H|| C C N. IH | H -- R, H R5 (b) Secondary structure R H H- R. H.... 0=C N-H. N-H.. ... H .• OC H N-H. R H C-R N-H -H H R Hydrogen bonds between amino acids at different locations in polypeptide chain H R HR a helix Pleated sheet (c) Tertiary structure (d) Quaternary structure Heme. Heme group B polypeptide FIGURE 9-3 A protein can have four levels of structure. (a) Primary structure. The sequence of amino acids defined by their R groups. (b) Secondary structure. The polypeptide can form a helical structure (an az helix) or a zigzag structure (a B-pleated sheet). The B-pleated sheet has two polypeptide segments arranged in opposite polarity, as indicated by the arrows. (c) Tertiary structure. The heme group is a nonprotein ring structure with an iron atom at its center. (d) Quatemary structure illustrated by hemoglobin, which is composed of four polypeptide subunits: two a subunits and two B subunits.
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