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family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) means sets of three codons removed to shorten sequence examined. XTI or

family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) means sets of three codons removed to shorten sequence examined. XTI or

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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3. A 72 year old man, Otto, has very poor vision caused by a network of protein fibers that form a lattice-like blockage in his eyes. His vision began failing when he was in his thirties. The man's 42-year old daughter Barbie developed vision loss and has the same defect as her father, the autosomal dominant condition lattice corneal dystrophy. Although symptoms generally begin after age 30, the first strands of protein in the eye can be seen by an ophthalmologist by the late teens. A mutation in the gene for a protein called gelsolin, which binds to the contractile protein actin, causes lattice corneal dystrophy. Gelsolin clears actin away after injury or inflammation. Compare the wild type or "normal" and Otto's family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template means sets of three codons removed to shorten sequence examined. (WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) WT DNA TGC AAG CTG TTA CGC CTG ACG AAG TAG GAC WT mRNA Amino Acid Family DNA Family mRNA Amino Acid TAC TAC ... ... 60 TGC AAG TTG TTA CGC CTG ACG AAG TAG GAC B. Circle the mutation and state the resulting changes in the polypeptide. : ... C. Give a short possible simple mechanistic hypothesis for the effect this mutation has had (how did this change in genotype/amino acid contribute to the change in phenotype ie vision damage), given the information at hand.
Transcribed Image Text:3. A 72 year old man, Otto, has very poor vision caused by a network of protein fibers that form a lattice-like blockage in his eyes. His vision began failing when he was in his thirties. The man's 42-year old daughter Barbie developed vision loss and has the same defect as her father, the autosomal dominant condition lattice corneal dystrophy. Although symptoms generally begin after age 30, the first strands of protein in the eye can be seen by an ophthalmologist by the late teens. A mutation in the gene for a protein called gelsolin, which binds to the contractile protein actin, causes lattice corneal dystrophy. Gelsolin clears actin away after injury or inflammation. Compare the wild type or "normal" and Otto's family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template means sets of three codons removed to shorten sequence examined. (WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) WT DNA TGC AAG CTG TTA CGC CTG ACG AAG TAG GAC WT mRNA Amino Acid Family DNA Family mRNA Amino Acid TAC TAC ... ... 60 TGC AAG TTG TTA CGC CTG ACG AAG TAG GAC B. Circle the mutation and state the resulting changes in the polypeptide. : ... C. Give a short possible simple mechanistic hypothesis for the effect this mutation has had (how did this change in genotype/amino acid contribute to the change in phenotype ie vision damage), given the information at hand.
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