Homework Help is Here – Start Your Trial Now!
Science
Biology
family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) means sets of three codons removed to shorten sequence examined. XTI or

family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) means sets of three codons removed to shorten sequence examined. XTI or

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question
3. A 72 year old man, Otto, has very poor vision caused by a network of protein fibers that form a lattice-like blockage in his eyes. His vision began failing when he was in his thirties. The man's 42-year old daughter Barbie developed vision loss and has the same defect as her father, the autosomal dominant condition lattice corneal dystrophy. Although symptoms generally begin after age 30, the first strands of protein in the eye can be seen by an ophthalmologist by the late teens. A mutation in the gene for a protein called gelsolin, which binds to the contractile protein actin, causes lattice corneal dystrophy. Gelsolin clears actin away after injury or inflammation. Compare the wild type or "normal" and Otto's family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template means sets of three codons removed to shorten sequence examined. (WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) WT DNA TGC AAG CTG TTA CGC CTG ACG AAG TAG GAC WT mRNA Amino Acid Family DNA Family mRNA Amino Acid TAC TAC ... ... 60 TGC AAG TTG TTA CGC CTG ACG AAG TAG GAC B. Circle the mutation and state the resulting changes in the polypeptide. : ... C. Give a short possible simple mechanistic hypothesis for the effect this mutation has had (how did this change in genotype/amino acid contribute to the change in phenotype ie vision damage), given the information at hand.
Transcribed Image Text:3. A 72 year old man, Otto, has very poor vision caused by a network of protein fibers that form a lattice-like blockage in his eyes. His vision began failing when he was in his thirties. The man's 42-year old daughter Barbie developed vision loss and has the same defect as her father, the autosomal dominant condition lattice corneal dystrophy. Although symptoms generally begin after age 30, the first strands of protein in the eye can be seen by an ophthalmologist by the late teens. A mutation in the gene for a protein called gelsolin, which binds to the contractile protein actin, causes lattice corneal dystrophy. Gelsolin clears actin away after injury or inflammation. Compare the wild type or "normal" and Otto's family DNA. (10 Pts) A. To compare, transcribe DNA to mRNA and translate (to amino acids) each DNA template means sets of three codons removed to shorten sequence examined. (WT & Family) for part of the gelsolin gene. Assume codons are as separated by spaces (...) WT DNA TGC AAG CTG TTA CGC CTG ACG AAG TAG GAC WT mRNA Amino Acid Family DNA Family mRNA Amino Acid TAC TAC ... ... 60 TGC AAG TTG TTA CGC CTG ACG AAG TAG GAC B. Circle the mutation and state the resulting changes in the polypeptide. : ... C. Give a short possible simple mechanistic hypothesis for the effect this mutation has had (how did this change in genotype/amino acid contribute to the change in phenotype ie vision damage), given the information at hand.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Genomics
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS