1. Indicate whether each of the following molecules is an alpha amino acid or not and explain why. a. H,N-CH-ċ-OH b. H,N-C-CH,CH,CH, CH-OH CH3 c. CH;CH,CH-CH2-NH, d. HO-C-CH-CH,CH(CH), NH2 2. Which of the following forms of lysine would you expect to predominate at low pH, neutral pH, and high pH? но но NH,-C-C-o (CH.), NH3-C-C-OH NH3-C-C-0 (CH)4 NH,+ a. b. CH)4 NH,+ NH2 3. One of the 20 standard amino acids is unusual in that its side chain contains a ring that incorporates the amine functional group of the amino acid. What is the name of this amino acid? What is its three-letter abbreviation and one-letter code? Write the chemical structure of this amino acid at physiological pH. 4. Draw the structure of valine at pH 1.0 and at pH 12.0.
1. Indicate whether each of the following molecules is an alpha amino acid or not and explain why. a. H,N-CH-ċ-OH b. H,N-C-CH,CH,CH, CH-OH CH3 c. CH;CH,CH-CH2-NH, d. HO-C-CH-CH,CH(CH), NH2 2. Which of the following forms of lysine would you expect to predominate at low pH, neutral pH, and high pH? но но NH,-C-C-o (CH.), NH3-C-C-OH NH3-C-C-0 (CH)4 NH,+ a. b. CH)4 NH,+ NH2 3. One of the 20 standard amino acids is unusual in that its side chain contains a ring that incorporates the amine functional group of the amino acid. What is the name of this amino acid? What is its three-letter abbreviation and one-letter code? Write the chemical structure of this amino acid at physiological pH. 4. Draw the structure of valine at pH 1.0 and at pH 12.0.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Topic 5_Proteins..
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1. Indicate whether each of the following molecules is an alpha amino acid or not and explain
why.
a. H,N-CH-C-OH
b.
H,N-C-CH,CH,CH;
CH-OH
ČH3
c. CH;CH;CH-CH,–NH,
HO-C
-CH-CH;CH(CH3)½
NH,
d.
OH
2. Which of the following forms of lysine would you expect to predominate at low pH, neutral
pH, and high pH?
H
но
H
NH,-
CH)4
NH,+
NH,-
(CH)4
NH,-
-C-O
C-Ĉ-OH
a.
b.
с.
(CH)4
NH,+
NH,
3. One of the 20 standard amino acids is unusual in that its side chain contains a ring that
incorporates the amine functional group of the amino acid. What is the name of this amino
acid? What is its three-letter abbreviation and one-letter code? Write the chemical structure
of this amino acid at physiological pH.
4. Draw the structure of valine at pH 1.0 and at pH 12.0.
26

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Topic 5_Proteins...
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Effective Date: 7-DEC-2016
5. In the introduction you learned that sickle-cell anemia is caused by the amino acid valine
substituting for aspartic acid as the sixth amino acid on the two beta-chains of hemoglobin.
Write the structure of these two amino acids at physiological pH. Are they polar or
nonpolar? If polar, indicate whether it is acidic, basic, or neutral.
6. Indicate whether the following foods are complete protein or incomplete protein source:
а.
b.
c.
d.
27
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Effective Date: 7-DEC-2016
PEPTIDES: COMBINATION OF AMINO ACIDS TO PROTEINS
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