. Does frame +2 have an ORF in the coding region of this exon? What about frame +1 and frame +3? Q11. Given that 3 of the 64 possible codons are stop codons, what is the chance of having a stop codon at any given position, assuming that the sequence is random?
Q10. Does frame +2 have an ORF in the coding region of this exon? What about frame +1 and frame +3?
Q11. Given that 3 of the 64 possible codons are stop codons, what is the chance of having a stop codon at any given position, assuming that the sequence is random?
Q 10 answer..
The second coding exon is in the +2 reading frame because it doesn't have any stop codons interrupting the exon like in the other two lines. For instance, exon 2 has an extra 2 nucleotides and exon 1 has an extra nucleotide so when they are joined together they will make a complete codon of three nucleotides. Since it is +2, when the exons are joined together and introns are spliced out, exon 1 will be in the +1 reading frame while exon two is in the +2 reading frame and the third exon is in the +3 reading frame so that when they are joined together, the codons are read in the correct pairs of three nucleotides.
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