Extra Credit #4 (1)

Directions: Read and internalize the short story below and answer the questions that follow. Complete solution is required. "The coronavirus disease (COVID-19) is an infectious disease caused by a new strain of coronavirus. This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019. On 30 January 2020, the Philippine Department of Health reported the first case of COVID-19 in the country with a 38-year-old female Chinese national. On 7 March, the first local transmission of COVID-19 was confirmed. WHO is working closely with the Department of Health in responding to the COVID-19 outbreak." Aki and her family were alarmed with the news they watched and so first thing in the morning they rush to the nearest convenient store to secure disinfectant and sanitizers but unfortunately the store aiready had empty shelves of the essentials they needed. They went to other stores searching and to their dismay they acquired nothing. They were on their way…

17. Which of the following scenarios DOES NOT point to the procurement of an assay?A. a certain type of grass is collected from a forest, and was analyzed for its overall mercury (Hg) content in its rootsB. a blood sample was taken from a dead dolphin for a complete genome sequencingC. human saliva is collected for the testing of covid-19 genomeD. a sample of urine was collected from a suspected drunk driver for analysis of phenolic compounds

4) Paxlovid is treatment for COVID-19 that was recently approved for use because it can drastically reduce the risk for hospitalization and death when taken early in the infection. It is actually a package of two different antiviral drugs. One of those is Nirmatrelvir, which is a modified tripeptide protein mimetic designed to covalently bind to and inhibit the main protease (MPro) from the SARS-CoV-2 virus. This protease recognizes and hydrolyzes peptide bonds at specific points in their sequence, and it is essential for viral replication. a. Below is one of the sequences that Mpro recognizes and cleaves. It cleaves the peptide bond between the glutamine and the glycine. Draw out the structure of a peptide with this sequence, including the appropriate stereochemistry for biological amino acids and assuming the peptide is at physiological pH (pH = 7.4). SGVTFQGKF b. What would the net charge of the peptide be at physiological pH?. c. At what pH would the peptide be net neutral?

Answer the following questions

Marie: The cell lines produce recombinant FIX and other proteins. Which biomolecule can specifically detect the presence of a certain protein, such as recombinant FIX, in a sample full of other proteins? a) Androgens b) Antigens c) Immunoglobulins d) Integrins

Discuss the medical impact and importance of viruses.

The Nat-Ca2+ exchanger is used to help regulate cardiac muscle function. It transports three Na* into the cell and one Ca²+ out of the cell in every cycle. What kind of transporter is the Nat-Ca2+ exchanger? Choose one: OA. Uniport B. Symport O C. Antiport Part 2 Digoxin is a drug used to treat heart failure by blocking the Nat-K* pump in cardiac cells. How would inhibition of the Nat-K+ pump alter the intracellular concentration of Ca²+?

8. Two substitution mutations are shown below; each changes an mRNA codon for an enzyme: UUA changes to AUA GAU changes to GUU One substitution has little effect on the biological activity of the enzyme, while the other is highly damaging. Predict which mutation will cause more damage, and justify your answer.

The indirect fluorescent antibody detection of anti-dsDNA uses which of the following as the antigen source?   Question 1 options:   A)  Hep 2 cell cultures   B)  mouse stomach sections   C)  Crithidia lucilliae kinetoplast   D)  monkey kidney cells

Activities acromolecules Fill in the table below to review macromolecules and their components (monomers). Macromolecule Examples Examples Macromolecules Components methionine, tyrosine, alanine. etc. (Polymer) Protein Nucleic Acid Carbohydrate 1 3 5 Components (Monomers) 2 Nucleotides 6 47 of