Human Anatomy
5th Edition
ISBN: 9780073403700
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 9.3, Problem 13BYGO
Summary Introduction
To write:
About the part that keeps the tibia bone from slipping off the talus sideways.
Introduction:
Tibia and talus are articulated at the knee joint or talocrural joint which has two articulations, namely, medial joint (present between talus and tibia) and lateral joint (present between talus and fibula).
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 9 Solutions
Human Anatomy
Ch. 9.1 - Prob. 1AWYKCh. 9.1 - Prob. 1BYGOCh. 9.1 - Prob. 2BYGOCh. 9.1 - Give some examples of joints that become...Ch. 9.1 - Prob. 4BYGOCh. 9.1 - Prob. 5BYGOCh. 9.1 - Prob. 6BYGOCh. 9.2 - Prob. 1AWYKCh. 9.2 - Prob. 2AWYKCh. 9.2 - What are the two components of a joint capsule?...
Ch. 9.2 - Give at least one example each of a monaxial,...Ch. 9.2 - Prob. 9BYGOCh. 9.3 - Where else in the body is there a structure...Ch. 9.3 - Prob. 10BYGOCh. 9.3 - Prob. 11BYGOCh. 9.3 - What keeps the femur from slipping backward off...Ch. 9.3 - Prob. 13BYGOCh. 9.4 - Define arthritis. How do the causes of...Ch. 9.4 - Prob. 15BYGOCh. 9 - Prob. 9.1.1AYLOCh. 9 - Prob. 9.1.2AYLOCh. 9 - Prob. 9.1.3AYLOCh. 9 - Prob. 9.1.4AYLOCh. 9 - Prob. 9.1.5AYLOCh. 9 - Prob. 9.1.6AYLOCh. 9 - Prob. 9.1.7AYLOCh. 9 - Prob. 9.2.1AYLOCh. 9 - Prob. 9.2.2AYLOCh. 9 - Prob. 9.2.3AYLOCh. 9 - Prob. 9.2.4AYLOCh. 9 - Prob. 9.2.5AYLOCh. 9 - Prob. 9.2.6AYLOCh. 9 - Prob. 9.2.7AYLOCh. 9 - Prob. 9.2.8AYLOCh. 9 - The same for elevation and drpessionCh. 9 - Prob. 9.2.10AYLOCh. 9 - Prob. 9.2.11AYLOCh. 9 - Prob. 9.2.12AYLOCh. 9 - Prob. 9.2.13AYLOCh. 9 - Prob. 9.2.14AYLOCh. 9 - The same for rotation of the head or torsoCh. 9 - The same for lateral and medial excursion of the...Ch. 9 - Prob. 9.2.17AYLOCh. 9 - Prob. 9.2.18AYLOCh. 9 - The same for the ankle or foot movements of...Ch. 9 - Prob. 9.2.20AYLOCh. 9 - Prob. 9.3.1AYLOCh. 9 - Prob. 9.3.2AYLOCh. 9 - Prob. 9.3.3AYLOCh. 9 - Prob. 9.3.4AYLOCh. 9 - Special functional qualities of the tibiofemoral...Ch. 9 - Prob. 9.3.6AYLOCh. 9 - The range of discorders included in the concept of...Ch. 9 - The general meaning of arthritis, and the...Ch. 9 - Prob. 9.4.3AYLOCh. 9 - Prob. 1TYRCh. 9 - Which of the following is the least movable? a...Ch. 9 - Prob. 3TYRCh. 9 - Prob. 4TYRCh. 9 - Prob. 5TYRCh. 9 - Prob. 6TYRCh. 9 - Prob. 7TYRCh. 9 - Prob. 8TYRCh. 9 - To bend backward at the waist involves ________ of...Ch. 9 - Prob. 10TYRCh. 9 - Th lubricant of a diarthrosis is _________.Ch. 9 - Prob. 12TYRCh. 9 - Prob. 13TYRCh. 9 - Prob. 14TYRCh. 9 - Prob. 15TYRCh. 9 - Prob. 16TYRCh. 9 - Prob. 17TYRCh. 9 - Prob. 18TYRCh. 9 - Prob. 19TYRCh. 9 - Prob. 20TYRCh. 9 - Prob. 1BYMVCh. 9 - Prob. 2BYMVCh. 9 - Prob. 3BYMVCh. 9 - Prob. 4BYMVCh. 9 - Prob. 5BYMVCh. 9 - Prob. 6BYMVCh. 9 - Prob. 7BYMVCh. 9 - Prob. 8BYMVCh. 9 - Prob. 9BYMVCh. 9 - State a meaning of each word element and give a...Ch. 9 - Prob. 1TOFCh. 9 - Prob. 2TOFCh. 9 - Prob. 3TOFCh. 9 - Determine which five of the following statements...Ch. 9 - Prob. 5TOFCh. 9 - Prob. 6TOFCh. 9 - Prob. 7TOFCh. 9 - Prob. 8TOFCh. 9 - Prob. 9TOFCh. 9 - Prob. 10TOFCh. 9 - Prob. 1TYCCh. 9 - Prob. 2TYCCh. 9 - In order of occurrence, list the joint actions...Ch. 9 - Prob. 4TYCCh. 9 - Prob. 5TYC
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