Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 9, Problem 5Q
Summary Introduction
To review:
The path of the radio-labeled carbon in the citric acid cycle (CAC) along with the reason behind two turns of this cycle is required to be run prior to the release of carbon atoms in the form of carbon dioxide (14 CO2).
Introduction:
The citric acid cycle is an essential biochemical pathway that releases chemical energy stored in the acetyl CoA. This process takes place inside the mitochondria. Acetyl CoA produced from the pyruvate by the enzyme pyruvate dehydrogenase. In CAC, two molecules of carbon dioxide get released in every turn of the cycle.
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trace the position of the elctron as this glucose molecule proceeds through glycolsis and two turns of the citric acid cycle
Acetyi CoA
Oxaloncetate
CoA
NADH
NAD:
Citrate
Isccitrate
Malate
NAD
co
NADH
Funaate
»FADH;
FAD
a- Ketoglutarate
Succinate
NAD
ATP
Succinyt CuA
NADH
ADP - P,
If you were told to add one of the eight citric acid cycle intermediates to the
culture medium fo yeast growing in the laboratory, what do you think would
happen to the rates of ATP and carbon dioxide production? (see the above
figure)
a. There would be no change in ATP production, but the rate of CO2
production would increase.
b. The rates of ATP production and CO2 production would both increase,
c. The rate of ATP production would increase, but the rate of CO2 production
would decrease.
d. The rates fo ATP and CO2 production would both decrease.
How many ATP molecules can be generated from one mol of 14CH3-COOH? (The conversion of acetate to acetyl-CoA requires the consumption of 2 ATP.)
Chapter 9 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 9 - Prob. 1QCh. 9 - Prob. 2QCh. 9 - Prob. 3QCh. 9 - Prob. 4QCh. 9 - Prob. 5QCh. 9 - Prob. 6QCh. 9 - Prob. 7QCh. 9 - Prob. 1RQCh. 9 - Prob. 2RQCh. 9 - Prob. 3RQ
Ch. 9 - Prob. 4RQCh. 9 - Prob. 5RQCh. 9 - Prob. 6RQCh. 9 - Prob. 7RQCh. 9 - Prob. 8RQCh. 9 - Prob. 9RQCh. 9 - Prob. 10RQCh. 9 - Prob. 11RQCh. 9 - Prob. 12RQCh. 9 - Prob. 13RQCh. 9 - Prob. 14RQCh. 9 - Prob. 15RQCh. 9 - Prob. 16RQCh. 9 - Prob. 17RQCh. 9 - Prob. 18RQCh. 9 - Prob. 19RQCh. 9 - Prob. 20RQCh. 9 - Prob. 21RQCh. 9 - Prob. 22RQCh. 9 - Prob. 23RQCh. 9 - Prob. 24RQCh. 9 - Prob. 25RQCh. 9 - Prob. 26RQCh. 9 - Prob. 27RQCh. 9 - Prob. 28FBCh. 9 - Prob. 29FBCh. 9 - Prob. 30FBCh. 9 - Prob. 31FBCh. 9 - Prob. 32FBCh. 9 - Prob. 33FBCh. 9 - Prob. 34FBCh. 9 - Prob. 35FBCh. 9 - Prob. 36FBCh. 9 - Prob. 37FBCh. 9 - Prob. 38SACh. 9 - Prob. 39SACh. 9 - Prob. 40SACh. 9 - Prob. 41SACh. 9 - Prob. 42SACh. 9 - Prob. 43TQCh. 9 - Prob. 44TQCh. 9 - Prob. 45TQCh. 9 - Prob. 46TQCh. 9 - Prob. 47TQCh. 9 - Prob. 48TQCh. 9 - Prob. 49TQCh. 9 - Prob. 50TQCh. 9 - Prob. 51TQCh. 9 - Prob. 52TQCh. 9 - Prob. 53TQCh. 9 - Prob. 54TQCh. 9 - Prob. 55TQCh. 9 - Prob. 56TQCh. 9 - Prob. 57TQCh. 9 - Prob. 58TQCh. 9 - Prob. 59TQ
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- [AktivGrid] Draw the product of the reaction of isocitrate catalyzed by isocitrate dehydrogenase in the TCA (citric acid) cycle. Provide the structure in the protonation state found in physiological conditions. 9 H-C-OH 800- -H CH₂ ° Coo of NAD+ dehydrogen isocitrate ase NADH, H*, Drawing CO2arrow_forwardPerform a pyruvate dehydrogenase reaction and a single turn of the citric acid cycle using an oxaloacetate molecule uniformly labeled with 18O and one pyruvate molecule uniformly labeled with 14C. Highlight the fate of all radioactively labeled atoms when complete.arrow_forwardDrawthe structures of the two citric acid cycle intermediates that can be converted into amino acids in a single step by transamination. What amino acids do they produce?Draw their structures.arrow_forward
- If a liver extract capable of carrying out normal metabolic reactions (including gluconeogenesis) is incubated with labeled pyruvate labeled with oxygen-18 at the carboxylate oxygen atom shown, where would the label be found in glucose? Explain both in words and illustration. If any of the positions be partially labeled, indicate that clearly and explain.arrow_forwardThe citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, please choose more than one. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4arrow_forwardHandwritten Identify the molecule names, enzyme name, enzyme classification and change in reaction(for glycolysis pathway)arrow_forward
- In step 7 of the citric acid cycle, fumarase catalyzes the addition of a water molecule to a carbon–carbon double bond (see Panel 13¬–2). Can this be considered an oxidation reaction? Explain your answer.arrow_forwarddraw acyl coa derived from docosanoic acid C21H43CO2Harrow_forwardGive the number of the reactions(s) of the citric acid cycle that reduce FAD give the order number of the reaction. If there is more than one reaction, give their order numbers in increasing order separated by commasarrow_forward
- Certain microorganisms with a modified citric acid cycle decarboxylate α-ketoglutarate to produce succinate semialdehyde:arrow_forwardConsider docosanoic acid C12H43CO2H a. Label the alpha and beta Carbons. Show the beta-oxidation in an EXPANDED structure. b. Draw each acyl CoA derived from this fatty acid. c. How many acetyl Co A molecules are formed by complete beta-oxidation? d. How many cycles of beta-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid? Show the complete computation. f. How many moles of ATP per gram of fatty acid is formed from the complete catabolism of the given fatty acid? g. What is the molar mass of the given fatty acid? Solution: Show here the complete computations, [from a to e]arrow_forwardwhich staments are falsearrow_forward
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