Chapter 9, Problem 11RQ

Summary Introduction

To review:

The conditions that indicate low energy status and providedescription of the impact that each of the following conditions will have on flux (through the citric acid cycle):

a. High NADH/NAD⁺ (Nicotinamide adenine dinucleotide) ratio

b. High ATP/ADP (adenosine triphosphate/adenosine diphosphate) ratio

c. High acetyl-CoA (Coenzyme A) concentration

d. Low citrate concentration

e. High succinyl-CoA concentration.

Introduction:

In mitochondri, aitricacid cycle occurs immediately after glycolysis. It is regulated by the cell’s energyrequirement. When the cellrequires energy, citric acid cycle is stimulate, dhereas it will in inhibited when energy is not needed.