Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 9, Problem 20ESP

Payne, B. A. et al. (2013) present evidence that a low level of heteroplasmic mtDNA exists in all tested healthy individuals.

  1. (a) What are two likely sources of such heteroplasmy?
  2. (b) What genetic conditions within a given mitochondrion are likely to contribute to such a variable pool of mitochondria?
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What is the simplest explanation for why patients have been identified with only one copy of the phosphofructokinase-1 gene (heterozygous), but no patients have been identified that lack both copies of the phosphofructokinase-1 gene (homozygous)? Patients lacking both copies of the phosphofructokinase-1 genes will be found once DNA sequencing technology can sequence whole genomes. Phosphofructokinase-1 is needed for nitrogen metabolism and there are no enzymes to replace this function, so cells die from ammonia toxicity. Phosphofructokinase-1 is a required enzyme for carbohydrate metabolism in all living cells, complete loss of this enzyme would be lethal. There are 6 phosphofructokinase-1 paralogous genes in humans and it is impossible to lack both type 1 copies when there are also types 4, 5, and 6.
What is the final result of mitosis in a human A) nearly genetically identical 2n somatic cells B) genetically different 2n somatic cells C) nearly genetically identical 1n somatic cells D) genetically identical 2n gamete cells   Which of the following statements is TRUE? A) A single, replicated chromosome with sister chromatids has two centromeres. B) A single, unreplicated chromosome has two DNA molecules. C) Sister chromatids from a single chromosome are connected at the centromere. D) Homologous chromosomes are connected at the centromere.   The first gap in the cell cycle (G1) corresponds to _____. A) normal growth and cell function B) the phase in which DNA is being replicated C) the beginning of mitosis D) the phase between DNA replication and the M phase   In a diploid cell from a specific species has 5 chromosome pairs, how many sister chromatids will be found in a nucleus at prophase of mitosis? (Draw it!) A) 5 B) 10 C) 20 D) 40 Consider a cell from the species above.…
Most organisms display a circadian rhythm, a cycling of biological processes that is roughly synchronized with day length.  In Drosophila, pupae eclose (emerge as adults after metamorphosis) at dawn. a)Using this knowledge how would screen for Drosophila mutants that have an impaired circadian rhythm? b)In each case, how would you clone the genes you identified by mutation?

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Concepts of Genetics (12th Edition)

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY