Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 8, Problem 22P

Chapters 6 and 7 explained that mistakes made by DNA polymerase are corrected either by proofreading mechanisms during DNA replication or by DNA repair systems that operate after replication is complete. The overall rate of errors in DNA replication is about 1×10-10, that is, one error in 10 million base pairs. RNA polymerase also has some proofreading capability, but the overall error rate for transcription is significantly higher (1×10-4, or one error in each 10,000 nucleotides). Why can organisms tolerate higher error rates for transcription than for DNA replication?

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Chapter 8 Solutions

Genetics: From Genes to Genomes, 5th edition

Ch. 8 - Before the technology existed to synthesize RNA...Ch. 8 - A particular protein has the amino acid sequence...Ch. 8 - Prob. 13PCh. 8 - How many possible open reading frames frames...Ch. 8 - a. In Fig. 8.3 on p. 257, the physical map the...Ch. 8 - Charles Yanofsky isolated many different trpA-...Ch. 8 - Remembering that the wobble base of the tRNA is...Ch. 8 - The sequence of a segment of mRNA, beginning with...Ch. 8 - You identify a proflavin-generated allele of a...Ch. 8 - In certain bacterial species, pyrrolysine Pyl,...Ch. 8 - Describe the steps in transcription that require...Ch. 8 - Chapters 6 and 7 explained that mistakes made by...Ch. 8 - The coding sequence for gene F is read from left...Ch. 8 - If you mixed the mRNA of a human gene with the...Ch. 8 - Describe the steps in translation that require...Ch. 8 - Locate as accurately as possible the listed items...Ch. 8 - Concerning the figure for Problem 26: a. Which...Ch. 8 - In prokaryotes, a search for genes in a DNA...Ch. 8 - The yeast gene encoding a protein found in the...Ch. 8 - The sequence of a complete eukaryotic gene...Ch. 8 - Using recombinant DNA techniques which will be...Ch. 8 - a. The genetic code table shown in Fig. 8.2 on p....Ch. 8 - Arrange the following list of eukaryotic gene...Ch. 8 - Concerning the list of eukaryotic gene elements in...Ch. 8 - The human gene for 2 lens crystallin has the...Ch. 8 - Do you think each of the following types of...Ch. 8 - Null mutations are valuable genetic resources...Ch. 8 - The following is a list of mutations that have...Ch. 8 - Considering further the mutations described in...Ch. 8 - When 1 million cells of a culture of haploid yeast...Ch. 8 - Why is a nonsense suppressor tRNATyr, even though...Ch. 8 - Prob. 42PCh. 8 - You are studying mutations in a bacterial gene...Ch. 8 - Another class of suppressor mutations, not...Ch. 8 - Yet another class of suppressor mutations not...Ch. 8 - There is at least one nonsense suppressing tRNA is...Ch. 8 - Prob. 47PCh. 8 - Brenners m mutant phages m1 m6 described in Fig....
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